Choi Jin Young, Choi Jaewan, Kim Yeon-Deok
HanGil Eye Hospital, Incheon, Korea.
Korean J Ophthalmol. 2010 Feb;24(1):47-52. doi: 10.3341/kjo.2010.24.1.47. Epub 2010 Feb 5.
This prospective observational case series study included 6 eyes of 6 consecutive glaucomatous patients. Each patient underwent trabeculectomy with mitomycin C, and received a 1.25 mg of subconjunctival bevacizumab injection at completion of the trabeculectomy. Study eyes included two with neovascular glaucoma, three with uveitic glaucoma, and one with secondary glaucoma following vitrectomy. All eyes had undergone failed glaucoma laser/surgical treatment or an intraocular surgical procedure. Intraocular pressure (IOP) at the following postoperative visits: preoperative, 1 week, 1 month, 2 months, 3 months, and 6 months, was measured. We also evaluated postoperative bleb findings and complications. IOP measured at each visit was 37.5+/-14.4 mmHg, 6.2+/-3.4 mmHg, 8.3+/-7.2 mmHg, 12.0+/-4.4 mmHg, 10.8+/-3.1 mmHg, and 12.2+/-3.3 mmHg, respectively, for each visit. All eyes had functioning blebs with normal IOP at postoperative 6 months with no additional IOP-lowering medication.
这项前瞻性观察性病例系列研究纳入了6例连续的青光眼患者的6只眼睛。每位患者均接受了丝裂霉素C小梁切除术，并在小梁切除术完成时结膜下注射1.25 mg贝伐单抗。研究眼包括2例新生血管性青光眼、3例葡萄膜炎性青光眼和1例玻璃体切除术后继发性青光眼。所有眼睛均曾接受青光眼激光/手术治疗失败或眼内手术。测量术后随访时（术前、1周、1个月、2个月、3个月和6个月）的眼压。我们还评估了术后滤过泡情况和并发症。每次随访时测量的眼压分别为37.5±14.4 mmHg、6.2±3.4 mmHg、8.3±7.2 mmHg、12.0±4.4 mmHg、10.8±3.1 mmHg和12.2±3.3 mmHg。所有眼睛在术后6个月时滤过泡功能良好，眼压正常，无需额外的降眼压药物。
