Wilgus Traci A, Ferreira Ahalia M, Oberyszyn Tatiana M, Bergdall Valerie K, Dipietro Luisa A
Department of Periodontics, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, IL 60612, USA.
Lab Invest. 2008 Jun;88(6):579-90. doi: 10.1038/labinvest.2008.36. Epub 2008 Apr 21.
Vascular endothelial growth factor (VEGF-A) is known for its effects on endothelial cells and as a positive mediator of angiogenesis. VEGF is thought to promote repair of cutaneous wounds due to its proangiogenic properties, but its ability to regulate other aspects of wound repair, such as the generation of scar tissue, has not been studied well. We examined the role of VEGF in scar tissue production using models of scarless and fibrotic repair. Scarless fetal wounds had lower levels of VEGF and were less vascular than fibrotic fetal wounds, and the scarless phenotype could be converted to a scar-forming phenotype by adding exogenous VEGF. Similarly, neutralization of VEGF reduced vascularity and decreased scar formation in adult wounds. These results show that VEGF levels have a strong influence on scar tissue formation. Our data suggest that VEGF may not simply function as a mediator of wound angiogenesis, but instead may play a more diverse role in the wound repair process.
血管内皮生长因子（VEGF - A）以其对内皮细胞的作用以及作为血管生成的正向介质而闻名。由于其促血管生成特性，VEGF被认为可促进皮肤伤口的修复，但其调节伤口修复其他方面（如瘢痕组织生成）的能力尚未得到充分研究。我们使用无瘢痕和纤维化修复模型研究了VEGF在瘢痕组织产生中的作用。无瘢痕的胎儿伤口VEGF水平较低，血管化程度低于纤维化的胎儿伤口，通过添加外源性VEGF可将无瘢痕表型转化为瘢痕形成表型。同样，中和VEGF可减少成年伤口的血管化并减少瘢痕形成。这些结果表明VEGF水平对瘢痕组织形成有强烈影响。我们的数据表明，VEGF可能不仅仅是伤口血管生成的介质，而是可能在伤口修复过程中发挥更多样化的作用。
