Scicchitano Bianca Maria, Rizzuto Emanuele, Musarò Antonio
Institute Pasteur Cenci-Bolognetti, Department of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome 00161, Italy.
Aging (Albany NY). 2009 May 13;1(5):451-7. doi: 10.18632/aging.100050.
Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, such as calpain, ubiquitin-proteasome and caspases, and to the alteration in muscle growth factors. Among them, insulin-like growth factor-1 (IGF-1) has been implicated in the control of skeletal muscle growth, differentiation, survival, and regeneration and has been considered a promising therapeutic agent in staving off the advance of muscle weakness. Here we review the molecular basis of muscle wasting associated with diseases, such as sarcopenia, muscular dystrophy and Amyotrophic Lateral Sclerosis, and discuss the potential therapeutic role of local IGF-1 isoforms in muscle aging and diseases.
大多数肌肉疾病的特征是由于慢性退化导致肌肉组织逐渐丧失，同时再生机制无法替代受损肌肉。这些病理变化，即肌肉萎缩，可归因于几种蛋白水解系统的激活，如钙蛋白酶、泛素-蛋白酶体和半胱天冬酶，以及肌肉生长因子的改变。其中，胰岛素样生长因子-1（IGF-1）与骨骼肌的生长、分化、存活和再生控制有关，并被认为是延缓肌肉无力进展的一种有前景的治疗药物。在此，我们综述了与少肌症、肌肉营养不良症和肌萎缩侧索硬化症等疾病相关的肌肉萎缩的分子基础，并讨论了局部IGF-1亚型在肌肉衰老和疾病中的潜在治疗作用。
