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It's all about balance: p53 and aging.

作者信息

Biteau Benoit, Jasper Heinrich

机构信息

Department of Biology, University of Rochester, Rochester, NY 14627, USA.

出版信息

Aging (Albany NY). 2009 Nov 13;1(11):884-6. doi: 10.18632/aging.100102.

DOI:10.18632/aging.100102
PMID:20157572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2815742/
Abstract
摘要

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It's all about balance: p53 and aging.一切都关乎平衡：p53与衰老。
Aging (Albany NY). 2009 Nov 13;1(11):884-6. doi: 10.18632/aging.100102.
2
p53, sex, and aging: lessons from the fruit fly.p53、性别与衰老：果蝇带来的启示
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Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.黑腹果蝇的p53对成虫寿命具有发育阶段特异性和性别特异性影响，这表明存在性拮抗多效性。
Aging (Albany NY). 2009 Oct 27;1(11):903-36. doi: 10.18632/aging.100099.
4
Antagonistic pleiotropy and p53.拮抗性多效性与p53
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The genetic architecture of aging: sexual antagonistic pleiotropy of p53 and foxo.衰老的遗传结构：p53和foxo的性拮抗多效性
Cell Cycle. 2010 Oct 1;9(19):3840-1. doi: 10.4161/cc.9.19.13464. Epub 2010 Oct 27.
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Down with p53!
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Long-Lived αMUPA Mice Show Reduced Sexual Dimorphism in Lifespan, and in Energy and Circadian Homeostasis-Related Parameters.长寿的αMUPA小鼠在寿命、能量及昼夜节律稳态相关参数方面表现出性二态性降低。
J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):451-60. doi: 10.1093/gerona/glv019. Epub 2015 Apr 11.
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Sir2 and longevity: the p53 connection.Sir2与长寿：p53关联
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Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation.褪黑素和姜黄改善衰老引起的变化：免疫球蛋白、细胞因子、DJ-1/NRF2及细胞凋亡调节的影响
Int J Physiol Pathophysiol Pharmacol. 2018 Apr 20;10(2):70-82. eCollection 2018.
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Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation.果蝇 p53 异构体差异调节细胞凋亡和凋亡诱导的增殖。
Cell Death Differ. 2013 Jan;20(1):108-16. doi: 10.1038/cdd.2012.100. Epub 2012 Aug 17.
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Hormesis does not make sense except in the light of TOR-driven aging.除了从TOR驱动的衰老角度来看，兴奋效应是没有意义的。
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Regulation of Drosophila lifespan by JNK signaling.JNK 信号通路对果蝇寿命的调控。
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The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.p53诱导的衰老与静止之间的选择部分由mTOR信号通路决定。
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本文引用的文献

1
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.黑腹果蝇的p53对成虫寿命具有发育阶段特异性和性别特异性影响，这表明存在性拮抗多效性。
Aging (Albany NY). 2009 Oct 27;1(11):903-36. doi: 10.18632/aging.100099.
2
dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.Sir2和Dmp53相互作用，介导黑腹果蝇中与CR相关的寿命延长的各个方面。
Aging (Albany NY). 2009 Jan;1(1):38-48. doi: 10.18632/aging.100001.
3
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.果蝇 FOXO 在雄性中起作用，导致组织特异性 p53 寿命影响的性别二态性。
Exp Gerontol. 2010 Feb;45(2):97-105. doi: 10.1016/j.exger.2009.10.009. Epub 2009 Oct 17.
4
20 years studying p53 functions in genetically engineered mice.20年致力于在基因工程小鼠中研究p53的功能。
Nat Rev Cancer. 2009 Nov;9(11):831-41. doi: 10.1038/nrc2731. Epub 2009 Sep 24.
5
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut.细胞因子/ Jak / Stat信号传导介导果蝇中肠的再生和内环境稳定。
Cell. 2009 Jun 26;137(7):1343-55. doi: 10.1016/j.cell.2009.05.014.
6
Sir2 and longevity: the p53 connection.Sir2与长寿：p53关联
Cell Cycle. 2009 Jun 15;8(12):1821. doi: 10.4161/cc.8.12.9010.
7
Telomerase reverse transcriptase delays aging in cancer-resistant mice.端粒酶逆转录酶延缓抗癌小鼠的衰老。
Cell. 2008 Nov 14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034.
8
Drosophila germ-line modulation of insulin signaling and lifespan.果蝇生殖系对胰岛素信号传导及寿命的调节
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6368-73. doi: 10.1073/pnas.0709128105. Epub 2008 Apr 23.
9
Cancer and ageing: convergent and divergent mechanisms.癌症与衰老：趋同和不同的机制
Nat Rev Mol Cell Biol. 2007 Sep;8(9):715-22. doi: 10.1038/nrm2242.
10
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.在成年果蝇大脑中表达显性负性Dmp53会抑制胰岛素信号传导。
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13355-60. doi: 10.1073/pnas.0706121104. Epub 2007 Aug 8.