Division of Molecular Biology and Cell Engineering, Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
Int J Hematol. 2010 Apr;91(3):360-72. doi: 10.1007/s12185-010-0517-9. Epub 2010 Feb 16.
Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have demonstrated that the pivotal transcription factors form a network. There they activate pluripotency-associated genes, including themselves, while repressing the developmentally regulated genes through co-occupation with various protein complexes. The chromatin structure characteristic of ES cells also contributes to the maintenance of the network. In this review, I focus on recent advances in our understanding of the transcriptional network that maintains pluripotency in mouse ES cells.
胚胎干细胞（ES 细胞）来源于囊胚，具有多能性。这种多能性引起了众多研究人员的兴趣，既为了扩展我们对发育生物学的基本理解，也为了在再生医学中的潜在应用。系统生物学研究表明，关键转录因子形成一个网络。在这个网络中，它们激活多能性相关基因，包括自身，同时通过与各种蛋白质复合物共同占据来抑制发育调控基因。ES 细胞的染色质结构特征也有助于网络的维持。在这篇综述中，我重点介绍了我们对维持小鼠 ES 细胞多能性的转录网络的理解的最新进展。
