Department of Medicine, Beth Israel Medical Center, University Hospital and Manhattan Campus for the Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA.
J Thromb Thrombolysis. 2010 Oct;30(3):281-5. doi: 10.1007/s11239-010-0442-z.
Nephrotic syndrome is known to cause venous thromboembolism (VTE) due to urine loss of antithrombin III and activation of the coagulation system. We hypothesized that the degree of proteinuria may predict the development of VTE. This was a retrospective case-controlled study of in-patients urban academic teaching hospital from April, 2007 to March, 2009 and who had undergone an imaging study for VTE. All radiology reports (N = 1,647) for CT angiography of chest and Doppler sonogram of extremities were reviewed. The following data were collected: race/ethnicity, degree of proteinuria on urinalysis, serum protein and albumin levels, risk factors for VTE and renal function. The study population consisted of 284 patients with VTE and 280 age/sex matched controls. Relative to those who did not have proteinuria, patients who tested positive for protein had a 3.4-fold increased risk of VTE (odds ratio (OR) 3.4, 95% confidence interval [2.4, 5.0]). The association was unchanged when adjusted for other risk factors. Patients with proteinuria may have an increased risk of venous thromboembolism.
肾病综合征会导致尿中抗凝血酶 III 丢失和凝血系统激活，从而引发静脉血栓栓塞症（VTE）。我们推测蛋白尿的程度可能可以预测 VTE 的发生。这是一项回顾性病例对照研究，研究对象为 2007 年 4 月至 2009 年 3 月期间在城市学术教学医院住院的患者，并进行了 VTE 的影像学检查。对所有进行 CT 血管造影和下肢多普勒超声的放射学报告（N=1647）进行了回顾。收集了以下数据：种族/民族、尿液分析中的蛋白尿程度、血清蛋白和白蛋白水平、VTE 风险因素和肾功能。研究人群包括 284 例 VTE 患者和 280 名年龄/性别匹配的对照。与那些没有蛋白尿的患者相比，尿蛋白阳性的患者 VTE 的风险增加了 3.4 倍（比值比（OR）3.4，95%置信区间[2.4，5.0]）。调整其他风险因素后，该关联仍然不变。有蛋白尿的患者可能有更高的静脉血栓栓塞风险。
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