慢性肾脏病中的静脉血栓栓塞：流行病学、蛋白尿的作用、慢性肾脏病严重程度及治疗方法
Venous thromboembolism in chronic kidney disease: epidemiology, the role of proteinuria, CKD severity and therapeutics.
作者信息
Dobrowolski Chrisanna, Clark Edward G, Sood Manish M
机构信息
Division of Internal Medicine, University of Ottawa, Ottawa, Canada.
Division of Nephrology, University of Ottawa, Ottawa, Canada.
出版信息
J Thromb Thrombolysis. 2017 Feb;43(2):241-247. doi: 10.1007/s11239-016-1437-1.
The worldwide prevalence of chronic kidney disease is 10-15 % of the adult population, is rising and increases susceptibility to venous thromboembolism (VTE). In this narrative review we discuss the underlying evidence behind the association of VTE/CKD and examine the role of worsening CKD stage, proteinuria, and the risk of recurrent VTE. As CKD may alter therapeutic options we discuss the role of emerging therapies, the non-vitamin K oral anticoagulants (NOAC), in the treatment of VTE.
全球慢性肾脏病的患病率在成年人口中为10%-15%，且呈上升趋势，同时增加了静脉血栓栓塞（VTE）的易感性。在这篇叙述性综述中，我们讨论VTE与CKD关联背后的潜在证据，并探讨CKD分期恶化、蛋白尿以及VTE复发风险的作用。由于CKD可能会改变治疗选择，我们讨论新兴疗法——非维生素K口服抗凝剂（NOAC）在VTE治疗中的作用。
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