Clinic of Children Diseases, Kaunas University of Medicine Hospital, Kaunas, Lithuania.
Rev Neurosci. 2009;20(3-4):261-6. doi: 10.1515/revneuro.2009.20.3-4.261.
To determine the safety and effectiveness of mild induced hypothermia in children after traumatic or posthypoxic brain injury. Thirteen patients after traumatic or poshypoxic brain injury were involved in the study. Mean age was 11.1 +/- 5.7 years. Median GCS 6 (3-8), PIM2 20.3 +/- 28.2%.
GOS 5 was assigned for six (46%) patients and GOS 4 for seven (54%) patients. Average GOS in patients after severe head trauma was 4.1 points; in patients with posthypoxic brain injury 5 points (p < 0.05). No life threatening complications occurred.
Mild induced hypothermia can be safely used in pediatric patients after severe traumatic or posthypoxic brain injury. This method may be of benefit while improving outcomes in children.
确定轻度诱导性低温在创伤性或缺氧后脑损伤后儿童中的安全性和有效性。本研究纳入了 13 名创伤性或缺氧后脑损伤患儿。平均年龄为 11.1 ± 5.7 岁。GCS 中位数为 6（3-8），PIM2 中位数为 20.3 ± 28.2%。
6 名（46%）患儿获得良好预后（GOS5），7 名（54%）患儿获得较好预后（GOS4）。严重颅脑损伤患儿的平均 GOS 为 4.1 分；缺氧性脑损伤患儿的平均 GOS 为 5 分（p<0.05）。未发生危及生命的并发症。
轻度诱导性低温可安全应用于严重创伤性或缺氧后脑损伤后的儿科患者。这种方法可能对改善患儿的预后有益。
