Burke Robin L, West Michael W, Erwin-Cohen Rebecca, Selby Edward B, Fisher Diana E, Twenhafel Nancy A
United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland, USA.
Comp Med. 2010 Feb;60(1):62-70.
Invasive Klebsiella pneumoniae with the hypermucoviscosity phenotype (HMV K. pneumoniae) is an emerging human pathogen that also has been attributed to fatal multisystemic disease in African green monkeys at our institution. Combining a cluster of subclinically infected macaques identified in March and April 2008 and the animals documented during a subsequent survey of more than 300 colony nonhuman primates yielded a total of 9 rhesus macaques and 6 cynomolgus macaques that were subclinically infected. In an attempt to propagate the responsible HMV K. pneumoniae strain, a subset of these animals was immunosuppressed with dexamethasone. None of the treated animals developed clinical disease consistent with the multisystemic disease that affected colony African green monkeys. However, cytokine analysis revealed significant alterations of secreted cytokines in macaques subclinically infected with HMV K. pneumoniae when compared with noninfected macaques, thereby calling into question the suitability of animals subclinically infected with HMV K. pneumoniae for use in immunologic or infectious disease research.
具有高黏液性表型的侵袭性肺炎克雷伯菌（HMV肺炎克雷伯菌）是一种新出现的人类病原体，在我们机构的非洲绿猴中，它还与致命的多系统疾病有关。将2008年3月和4月确定的一群亚临床感染猕猴与随后对300多只圈养非人灵长类动物进行调查时记录的动物相结合，共有9只恒河猴和6只食蟹猴受到亚临床感染。为了繁殖致病的HMV肺炎克雷伯菌菌株，对其中一部分动物用 dexamethasone进行免疫抑制。没有一只接受治疗的动物出现与影响圈养非洲绿猴的多系统疾病相符的临床疾病。然而，细胞因子分析显示，与未感染的猕猴相比，亚临床感染HMV肺炎克雷伯菌的猕猴分泌的细胞因子有显著变化，从而使人质疑亚临床感染HMV肺炎克雷伯菌的动物用于免疫或传染病研究的适用性。
