IVF Unit, Queen Sophia Hospital, Box 5605, 114 86 Stockholm, Sweden.
Reprod Biomed Online. 2010 Jan;20(1):156-62. doi: 10.1016/j.rbmo.2009.10.017. Epub 2009 Oct 31.
Modified natural cycle IVF (mnc-IVF) or mild IVF (m-IVF) was offered to selected patients between 1996 and 2007; 43 patients during 129 cycles were treated with mnc-IVF and 145 couples during 250 cycles were treated with m-IVF. Comparison with outcome from conventional IVF cycles during the same time period and in the same clinic was performed. Although 53.5 and 39.6% of started cycles respectively never reached embryo transfer, the ongoing pregnancy rates per embryo transfer were 26.7% for mnc-IVF and 27.2% for m-IVF. During the same time period, cancellation rate for conventional IVF was 13.7% and the ongoing pregnancy rate per embryo transfer was 34.3%. For patients > or =38years of age, the ongoing pregnancy rate per embryo transfer was 17.5% in the m-IVF group. None of the patients aged > or =38years in the mnc-IVF group achieved an ongoing pregnancy. For patients treated with conventional IVF, the > or =38years of age pregnancy rate per embryo transfer was 27.0%. Costs of medication for m-IVF and mnc-IVF were 96.3 and 97.5% less than for the least expensive conventional IVF cycle respectively. Pregnancy rates per embryo transfer are acceptable for these treatment modalities, the cost for medication is low, risks for complications are dramatically reduced, and the treatments may be more psychologically acceptable to the patients.
改良自然周期 IVF（mnc-IVF）或温和 IVF（m-IVF）于 1996 年至 2007 年期间提供给选定的患者；在 129 个周期中，43 名患者接受 mnc-IVF 治疗，在 250 个周期中，145 对夫妇接受 m-IVF 治疗。与同期同诊所常规 IVF 周期的结果进行了比较。尽管分别有 53.5%和 39.6%的起始周期从未进行胚胎移植，但 mnc-IVF 的胚胎移植持续妊娠率为 26.7%，m-IVF 为 27.2%。同期，常规 IVF 的取消率为 13.7%，胚胎移植的持续妊娠率为 34.3%。对于年龄>或=38 岁的患者，m-IVF 组的胚胎移植持续妊娠率为 17.5%。mnc-IVF 组中没有年龄>或=38 岁的患者实现持续妊娠。对于接受常规 IVF 治疗的患者，年龄>或=38 岁的患者胚胎移植的妊娠率为 27.0%。m-IVF 和 mnc-IVF 的药物治疗费用分别比最便宜的常规 IVF 周期低 96.3%和 97.5%。这些治疗方法的胚胎移植妊娠率可接受，药物治疗费用低，并发症风险显著降低，并且这些治疗方法可能更能被患者接受。
