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2
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本文引用的文献

1
Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity.肥胖对口服避孕药药代动力学及下丘脑-垂体-卵巢活性的影响。
Contraception. 2009 Aug;80(2):119-27. doi: 10.1016/j.contraception.2009.04.011. Epub 2009 Jun 4.
2
Body size affects measures of ovarian reserve in late reproductive age women.体型会影响晚育年龄女性的卵巢储备指标。
Menopause. 2008 Sep-Oct;15(5):857-61. doi: 10.1097/gme.0b013e318165981e.
3
Relationship of serum antimüllerian hormone concentration to age at menopause.血清抗苗勒管激素浓度与绝经年龄的关系。
J Clin Endocrinol Metab. 2008 Jun;93(6):2129-34. doi: 10.1210/jc.2007-2093. Epub 2008 Mar 11.
4
Serum anti-mullerian hormone levels and follicular cohort characteristics after pituitary suppression in the late luteal phase with oral contraceptive pills.口服避孕药在黄体晚期抑制垂体后血清抗苗勒管激素水平及卵泡群特征
Hum Reprod. 2007 Dec;22(12):3192-6. doi: 10.1093/humrep/dem258. Epub 2007 Nov 2.
5
Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids.血清抗苗勒管激素水平在整个月经周期以及口服或经阴道给予合成性类固醇后保持稳定。
Fertil Steril. 2008 Aug;90(2):395-400. doi: 10.1016/j.fertnstert.2007.06.023. Epub 2007 Oct 24.
6
Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-Müllerian hormone and inhibin-B.卵泡内雄激素水平升高会影响人颗粒细胞抗苗勒管激素和抑制素B的分泌。
Fertil Steril. 2008 Jun;89(6):1760-5. doi: 10.1016/j.fertnstert.2007.05.003. Epub 2007 Jul 12.
7
Müllerian-inhibiting substance inhibits cytochrome P450 aromatase activity in human granulosa lutein cell culture.苗勒管抑制物质抑制人颗粒黄体细胞培养中的细胞色素P450芳香化酶活性。
Fertil Steril. 2008 May;89(5 Suppl):1364-70. doi: 10.1016/j.fertnstert.2007.03.066. Epub 2007 May 22.
8
Anti-Müllerian hormone levels during hormonal contraception in women with polycystic ovary syndrome.多囊卵巢综合征女性激素避孕期间的抗苗勒管激素水平
Eur J Obstet Gynecol Reprod Biol. 2007 Oct;134(2):196-201. doi: 10.1016/j.ejogrb.2007.01.012. Epub 2007 Mar 1.
9
Association of anti-mullerian hormone levels with obesity in late reproductive-age women.晚育年龄女性抗苗勒管激素水平与肥胖的关系。
Fertil Steril. 2007 Jan;87(1):101-6. doi: 10.1016/j.fertnstert.2006.05.074. Epub 2006 Nov 15.
10
Adiponectin induces periovulatory changes in ovarian follicular cells.脂联素可诱导卵巢滤泡细胞发生排卵周变化。
Endocrinology. 2006 Nov;147(11):5178-86. doi: 10.1210/en.2006-0679. Epub 2006 Aug 17.

抗苗勒氏管激素与肥胖：口服避孕药使用者的新认识。

Antimullerian hormone and obesity: insights in oral contraceptive users.

机构信息

Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599, USA.

出版信息

Contraception. 2010 Mar;81(3):245-8. doi: 10.1016/j.contraception.2009.10.004. Epub 2009 Nov 14.

DOI:10.1016/j.contraception.2009.10.004
PMID:20159182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2824609/
Abstract

BACKGROUND

The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women.

STUDY DESIGN

Ovulatory women, ages 18-35 years, of normal (<25 kg/m(2); n=10) and obese (>30 kg/m(2); n=10) body mass index (BMI) received a low-dose OC (20 mcg ethinyl estradiol/100 mcg levonorgestrel) for two cycles. Serum samples obtained at several time points during active pill use and hormone-free intervals were analyzed for AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and inhibin B.

RESULTS

AMH levels did not differ by OC cycle day in either BMI group. On average, AMH levels were 34% lower in the obese group (2.9+/-2.1 vs. 4.4+/-1.8 ng/mL, p<.05). Modeling to determine differences in AMH throughout the cycle based on obesity status demonstrated significantly lower levels (p<.05), whereas serum AMH, FSH, LH, estradiol and inhibin B levels revealed no correlations when all time points were included.

CONCLUSIONS

In reproductive-age women, serum AMH levels do not appear to fluctuate during OC use, but AMH levels are significantly lower in obese women. Lower levels do not appear to be due to differences in gonadotropin levels or ovarian activity.

摘要

背景

本研究旨在探讨肥胖状态对生育期妇女口服避孕药（OC）对血清抗苗勒管激素（AMH）水平的影响。

研究设计

18-35 岁排卵正常（<25 kg/m²；n=10）和肥胖（>30 kg/m²；n=10）的女性接受低剂量 OC（20 mcg 炔雌醇/100 mcg 左炔诺孕酮）治疗两个周期。在服用活性药物和激素间期的几个时间点采集血清样本，分析 AMH、卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇和抑制素 B。

结果

在两个 BMI 组中，AMH 水平在 OC 周期天数上均无差异。肥胖组的 AMH 水平平均低 34%（2.9+/-2.1 vs. 4.4+/-1.8 ng/mL，p<.05）。根据肥胖状态对整个周期 AMH 差异进行建模表明，AMH 水平显著降低（p<.05），而血清 AMH、FSH、LH、雌二醇和抑制素 B 水平在纳入所有时间点时无相关性。

结论

在生育期妇女中，OC 使用期间血清 AMH 水平似乎不波动，但肥胖女性的 AMH 水平显著降低。低水平似乎不是由于促性腺激素水平或卵巢活动的差异所致。