Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
J Allergy Clin Immunol. 2010 Feb;125(2):312-8. doi: 10.1016/j.jaci.2009.12.936.
The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here.
2009 年，在哮喘和其他过敏性疾病发病机制的细胞和化学机制方面的研究取得了快速进展。《过敏与临床免疫学杂志》（Journal of Allergy and Clinical Immunology）发表的研究描述了我们在哮喘和疾病模型中信号分子和途径、细胞因子以及激活和耐受方面的知识进展；食物过敏；过敏反应和即刻超敏反应；肥大细胞及其疾病；特应性皮炎；过敏性结膜炎；鼻息肉；嗜酸性粒细胞增多综合征。其他研究提供了关于过敏性炎症的诱导和调节以及哮喘和对哮喘治疗反应的遗传决定因素的新信息。本文总结了这些研究的关键特征及其对人类变态反应性疾病的潜在影响。
