Morristown Memorial Hospital Residency in Emergency Medicine, Morristown, NJ 07962, USA.
Am J Emerg Med. 2010 Feb;28(2):166-9. doi: 10.1016/j.ajem.2008.10.035.
A previous study showed that pulmonary edema patients presenting between noon and 4 pm have the highest rates of myocardial infarction and death. We hypothesized that the highest intubation rates would also occur at these times.
We performed a retrospective cohort study of consecutive patients seen by emergency department physicians in 15 hospital emergency departments (1996-2003).
Of 3.6 million visits in the database, 39,795 (1.1%) patients had congestive heart failure. We found statistically significant circadian variations in intubation rates. Patients arriving between midnight and 4 am had the highest intubation rates (4.1%), and those arriving between noon and 4 pm had the lowest (1.2%) (difference, 2.9%; 95% confidence interval, 2.4%-3.4%; P < .0001).
We found significant circadian variation in intubation rates, with a marked increase around midnight. Pathological mechanisms causing patients with congestive heart failure to require intubation may differ from those resulting in myocardial infarction or death.
先前的一项研究表明,中午 12 点至下午 4 点之间出现肺水肿的患者心肌梗死和死亡的发生率最高。我们假设在这些时间点也会出现最高的插管率。
我们对 15 家医院急诊科的急诊医生连续诊治的患者进行了回顾性队列研究。
在数据库中的 360 万次就诊中,有 39795 名(1.1%)患者患有充血性心力衰竭。我们发现插管率存在明显的昼夜节律变化。午夜至凌晨 4 点到达的患者插管率最高(4.1%),而中午至下午 4 点到达的患者插管率最低(1.2%)(差异为 2.9%;95%置信区间为 2.4%-3.4%;P<.0001)。
我们发现插管率存在显著的昼夜节律变化,午夜前后明显增加。导致充血性心力衰竭患者需要插管的病理机制可能与导致心肌梗死或死亡的机制不同。