Department of Community Health, Brown University, Providence, RI, USA.
Ann Epidemiol. 2010 Mar;20(3):201-9. doi: 10.1016/j.annepidem.2009.11.013.
Describing weight trajectories using functional methods may further our understanding of how weight impacts health. We characterize weight patterns and describe correlates of these patterns.
Using a subset of the Framingham Heart Study original cohort limited-access data set (n=1,429), we conducted a functional principal components analysis (PCA) of body mass index from 40 to 55 years of age. Scores from the principal component functions defined weight patterns. Gender-specific logistic regression models provided estimates of association with sociodemographic and lifestyle factors.
Overall weight status, weight changes, and cycling emerged as weight patterns during middle age. Overweight/obesity at 25 years was the most consistent correlate of weight patterns (adjusted odds ratios [AORs] for men and women were 14.2 and 3.7 for overall overweight, 99.5 and 28.3 for overall obese, and 1.4 and 3.9 for cycling). Weight status at 25 years was not associated with weight gain in either gender or weight loss in men; for women the AOR was 2.7 for weight loss.
Functional PCA described weight patterns during middle age. The strong associations between weight status at 25 years and overall weight status and cycling during middle age underscore the importance of addressing weight earlier in life.
使用功能方法描述体重轨迹可以帮助我们进一步了解体重对健康的影响。我们描述了体重模式，并描述了这些模式的相关因素。
我们使用弗雷明汉心脏研究原始队列有限访问数据集的一个子集（n=1429），对 40 至 55 岁时的体重指数进行了功能主成分分析（PCA）。主成分函数的得分定义了体重模式。性别特异性的逻辑回归模型提供了与社会人口统计学和生活方式因素关联的估计。
总体体重状况、体重变化和体重波动在中年期间出现了体重模式。25 岁时超重/肥胖是体重模式最一致的相关因素（男性和女性的调整后比值比[OR]分别为总体超重的 14.2 和 3.7，总体肥胖的 99.5 和 28.3，以及循环的 1.4 和 3.9）。25 岁时的体重状况与两性的体重增加或男性的体重减轻无关；对于女性，体重减轻的 OR 为 2.7。
功能 PCA 描述了中年时期的体重模式。25 岁时的体重状况与中年时期的总体体重状况和体重波动之间的强烈关联强调了在生命早期解决体重问题的重要性。
