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胰腺囊性肿瘤

Cystic neoplasms of the pancreas.

作者信息

Tran Cao Hop S, Kellogg Benjamin, Lowy Andrew M, Bouvet Michael

机构信息

Department of Surgery, Moores Cancer Center, University of California, San Diego School of Medicine, 3855 Health Sciences Drive, La Jolla, CA 92093-0803, USA.

出版信息

Surg Oncol Clin N Am. 2010 Apr;19(2):267-95. doi: 10.1016/j.soc.2009.11.004.

DOI:10.1016/j.soc.2009.11.004
PMID:20159515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4383087/
Abstract

Cystic neoplasms of the pancreas are a heterogeneous group of pancreatic tumors that vary in pathophysiology, malignant potential, clinical course, and outcomes. Their management is heavily predicated on establishing an accurate diagnosis. This can be particularly challenging, but can often be achieved by a thorough history and physical examination combined with high-quality, thin-slice computed tomography, although additional diagnostic tools may be required. Once the diagnosis is established, treatment can range from simple observation to total pancreatectomy. This decision rests on a clear and complete understanding of each disease process in the context of the patient's age and comorbidities. This article reviews the most common cystic neoplasms of the pancreas, focusing on their diagnosis and management.

摘要

胰腺囊性肿瘤是一组异质性的胰腺肿瘤,其病理生理学、恶性潜能、临床病程及预后各不相同。对它们的处理很大程度上取决于能否做出准确诊断。这可能极具挑战性,但通常通过详尽的病史和体格检查,再结合高质量的薄层计算机断层扫描来实现,不过可能还需要其他诊断工具。一旦确诊,治疗方案可从单纯观察到全胰切除术不等。这一决策取决于在患者年龄和合并症背景下对每个疾病过程的清晰且全面的了解。本文综述了胰腺最常见的囊性肿瘤,重点关注其诊断和处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f6/4383087/52683b176707/nihms674440f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f6/4383087/52683b176707/nihms674440f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f6/4383087/bdc73227b67f/nihms674440f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f6/4383087/274bce665f2b/nihms674440f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f6/4383087/52683b176707/nihms674440f8.jpg

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本文引用的文献

1
Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas.胰腺恶性导管内乳头状黏液性肿瘤中K-ras突变增加以及S100A4和MUC2蛋白表达增加。
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Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients.190例患者回顾性系列研究中的分支导管内乳头状黏液性肿瘤
Br J Surg. 2009 Apr;96(4):405-11. doi: 10.1002/bjs.6557.
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Single-institution validation of the international consensus guidelines for treatment of branch duct intraductal papillary mucinous neoplasms of the pancreas.胰腺分支导管内乳头状黏液性肿瘤治疗国际共识指南的单机构验证
J Hepatobiliary Pancreat Surg. 2009;16(3):353-8. doi: 10.1007/s00534-009-0068-8. Epub 2009 Mar 12.
4
Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma.胰腺导管内乳头状黏液性肿瘤的全基因组分析显示,与导管腺癌相比,存在显著的分子差异。
Ann Surg. 2009 Mar;249(3):440-7. doi: 10.1097/SLA.0b013e31819a6e16.
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Management of mucin-producing cystic neoplasms of the pancreas.胰腺黏液性囊性肿瘤的管理
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Cystic neoplasms of the pancreas: a diagnostic challenge.胰腺囊性肿瘤:一项诊断挑战。
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Pancreatic pseudocyst.胰腺假性囊肿
World J Gastroenterol. 2009 Jan 7;15(1):38-47. doi: 10.3748/wjg.15.38.
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Intraductal papillary mucinous neoplasm--when to resect?导管内乳头状黏液性肿瘤——何时进行切除?
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Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas.52例胰腺导管内乳头状黏液性肿瘤的组织学、免疫组化及分子分类
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