囊性和实性胰腺偶发瘤的管理:一项综述分析

Management of cystic and solid pancreatic incidentalomas: a review analysis.

作者信息

Karatzas T, Dimitroulis D, Charalampoudis P, Misiakos E P, Vasileiadis I, Kouraklis G

机构信息

Second Propedeutic Department of Surgery, University of Athens Medical School, Athens, Greece.

出版信息

J BUON. 2013 Jan-Mar;18(1):17-24.

DOI:
Abstract

Incidentally discovered pancreatic lesions that are asymptomatic have become much more common in recent years. It is important to characterize these lesions and to determine which patients can be safely observed and which should undergo an operation, as a substantial proportion of them might be malignant or premalignant. This review focus on the diagnostic approach and management of the different types of cystic and solid incidental pancreatic lesions based on appropriate clinical input, imaging screening and histological criteria. The task of developing guidelines to deal with an incidentally found pancreatic lesion, however, is much more complex and controversial than with other organs incidentalomas. In most series, pancreatic incidentalomas (PIs) <2 cm and of cystic appearance are likely to be benign, whereas those >2 cm are usually premalignant or malignant. Serous cystadenomas can reach very large size and are usually benign lesions. The presence of a solid mass or a mural nodule in a cystic lesion along with main pancreatic duct dilatation, thick septations and biliary obstruction are considered features suspicious of malignancy. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are malignant or lesions of malignant potential and need surgical exploration. Solid lesions are much more likely to be premalignant or malignant and most of patients will undergo resection. The decision to operate rather than follow a solid lesion is a matter of tumor size and of clinical judgment based on the age and patient comorbidities. The present study should serve as a general guide and not applied as strict principles. Key words: cystic pancreatic incidentalomas, diagnostic approach, management, solid pancreatic incidentalomas.

摘要

近年来,偶然发现的无症状胰腺病变变得越来越常见。明确这些病变的特征,并确定哪些患者可以安全观察,哪些患者应接受手术,这一点很重要,因为其中相当一部分可能是恶性或癌前病变。本综述基于适当的临床信息、影像筛查和组织学标准,重点探讨不同类型的囊性和实性偶然胰腺病变的诊断方法和管理。然而,制定处理偶然发现的胰腺病变的指南的任务,比处理其他器官的偶发瘤要复杂和有争议得多。在大多数系列研究中,直径<2 cm且呈囊性外观的胰腺偶发瘤(PI)可能是良性的,而那些>2 cm的通常是癌前病变或恶性病变。浆液性囊腺瘤可以长得非常大,通常是良性病变。囊性病变中出现实性肿块或壁结节,同时伴有主胰管扩张、厚分隔和胆管梗阻,被认为是可疑恶性的特征。黏液性囊性肿瘤和导管内乳头状黏液性肿瘤是恶性或具有恶性潜能的病变,需要手术探查。实性病变更有可能是癌前病变或恶性病变,大多数患者将接受切除。决定对实性病变进行手术而不是观察,取决于肿瘤大小以及基于患者年龄和合并症的临床判断。本研究应作为一般指南,而非严格原则应用。关键词:囊性胰腺偶发瘤、诊断方法、管理、实性胰腺偶发瘤

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