豚鼠肺的生化成熟与早产后的存活情况

Biochemical maturation of the guinea pig lung and survival following premature delivery.

Kelly F J, Rickett G M, Hunt A N, Town G I, Holgate S T, Postle T D

Department of Human Nutrition, University of Southampton, England.

Int J Biochem. 1991;23(4):467-71. doi: 10.1016/0020-711x(91)90175-m.

Abstract

Viable preterm guinea pigs were delivered by Caesarean section from 62 day gestation (term = 68 days). 2. Survival rates (24 hr) were greater than 90%, greater than 55% and greater than 35% respectively at 65, 63 and 62 days gestation. Guinea pig pups experienced increasing respiratory difficulty with progressive prematurity. 3. Lung phosphatidylcholine concentration increased steadily from 0.52 +/- 0.09 mumol/mg DNA at day 50 to 3.9 +/- 0.5 mumol/mg DNA at term. The relative contribution of the disaturated dipalmitoyl species increased over this time from 24.5 to 42.9%. 4. Pulmonary antioxidant capacity increased markedly over the final eight days of gestation, individual increases being manganese superoxide dismutase 68%, copper/zinc superoxide dismutase 48%, glutathione peroxide 37% and catalase 198%.

摘要

妊娠62天（足月为68天）的早产豚鼠通过剖宫产分娩。2. 在妊娠65天、63天和62天时，24小时存活率分别大于90%、大于55%和大于35%。豚鼠幼崽随着早产程度的增加，呼吸困难也日益加重。3. 肺磷脂酰胆碱浓度从第50天的0.52±0.09微摩尔/毫克DNA稳步增加至足月时的3.9±0.5微摩尔/毫克DNA。在此期间，二饱和二棕榈酰物种的相对贡献从24.5%增加到42.9%。4. 在妊娠的最后八天，肺抗氧化能力显著增强，其中锰超氧化物歧化酶增加68%，铜/锌超氧化物歧化酶增加48%，谷胱甘肽过氧化物增加37%，过氧化氢酶增加198%。