Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Dev Cell. 2010 Feb 16;18(2):169-70. doi: 10.1016/j.devcel.2010.01.012.
In this issue of Developmental Cell, Kernohan et al. link the chromatin regulatory proteins ATRX, MeCP2, CTCF, and cohesin with silencing of H19 and other imprinted genes during critical stages of postnatal brain development, perhaps suggesting a common etiology for several human diseases that exhibit defects in brain development and function.
在本期《发育细胞》中,Kernohan 等人将染色质调节蛋白 ATRX、MeCP2、CTCF 和黏连蛋白与 H19 和其他印迹基因在出生后大脑发育的关键阶段的沉默联系起来,这也许表明了几种表现出大脑发育和功能缺陷的人类疾病具有共同的病因。