染色质修饰物、认知障碍和印迹基因。
Chromatin modifiers, cognitive disorders, and imprinted genes.
机构信息
Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
出版信息
Dev Cell. 2010 Feb 16;18(2):169-70. doi: 10.1016/j.devcel.2010.01.012.
Abstract
In this issue of Developmental Cell, Kernohan et al. link the chromatin regulatory proteins ATRX, MeCP2, CTCF, and cohesin with silencing of H19 and other imprinted genes during critical stages of postnatal brain development, perhaps suggesting a common etiology for several human diseases that exhibit defects in brain development and function.
摘要
在本期《发育细胞》中，Kernohan 等人将染色质调节蛋白 ATRX、MeCP2、CTCF 和黏连蛋白与 H19 和其他印迹基因在出生后大脑发育的关键阶段的沉默联系起来，这也许表明了几种表现出大脑发育和功能缺陷的人类疾病具有共同的病因。
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本文引用的文献
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2
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.在生殖系发育过程中，多个印记基因座的非等位基因转位由H19印记控制区组织。
Genes Dev. 2009 Nov 15;23(22):2598-603. doi: 10.1101/gad.552109.
3
Regulation of imprinting in clusters: noncoding RNAs versus insulators.基因簇中印迹的调控：非编码RNA与绝缘子
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Nat Rev Neurosci. 2007 Nov;8(11):832-43. doi: 10.1038/nrn2235.
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