Department of Reproductive Medicine, University of California, San Diego, Moores Cancer Center, La Jolla, CA 92093, USA.
Dev Cell. 2010 Feb 16;18(2):170-2. doi: 10.1016/j.devcel.2010.01.013.
Transmembrane growth factor and integrin matrix receptors form multiprotein signaling complexes with FAK, a cytoplasmic cell motility-associated kinase. In a recent issue of Molecular Cell, Long et al. now show that a PAK-phosphorylated alternate-spliced isoform of the steroid receptor coactivator-3 (SRC-3Delta4) bridges EGFR and FAK, enhancing breast carcinoma cell migration and metastasis.
跨膜生长因子和整合素基质受体与细胞质细胞运动相关激酶 FAK 形成多蛋白信号复合物。在最近一期的《分子细胞》杂志上，Long 等人现在表明，类固醇受体共激活因子-3（SRC-3Delta4）的一种 PAK 磷酸化的选择性剪接异构体可连接 EGFR 和 FAK，从而增强乳腺癌细胞的迁移和转移。
