一种激活 EGFR 和 FAK 的 PAK 连接蛋白。
A PAK-activated linker for EGFR and FAK.
机构信息
Department of Reproductive Medicine, University of California, San Diego, Moores Cancer Center, La Jolla, CA 92093, USA.
出版信息
Dev Cell. 2010 Feb 16;18(2):170-2. doi: 10.1016/j.devcel.2010.01.013.
Abstract
Transmembrane growth factor and integrin matrix receptors form multiprotein signaling complexes with FAK, a cytoplasmic cell motility-associated kinase. In a recent issue of Molecular Cell, Long et al. now show that a PAK-phosphorylated alternate-spliced isoform of the steroid receptor coactivator-3 (SRC-3Delta4) bridges EGFR and FAK, enhancing breast carcinoma cell migration and metastasis.
摘要
跨膜生长因子和整合素基质受体与细胞质细胞运动相关激酶 FAK 形成多蛋白信号复合物。在最近一期的《分子细胞》杂志上，Long 等人现在表明，类固醇受体共激活因子-3（SRC-3Delta4）的一种 PAK 磷酸化的选择性剪接异构体可连接 EGFR 和 FAK，从而增强乳腺癌细胞的迁移和转移。
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本文引用的文献
1
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2
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J Cell Sci. 2009 Jun 1;122(Pt 11):1852-62. doi: 10.1242/jcs.046870. Epub 2009 May 12.
3
The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.核受体共激活因子AIB1在乳腺癌中的作用与调控
Breast Cancer Res Treat. 2009 Jul;116(2):225-37. doi: 10.1007/s10549-009-0405-2. Epub 2009 May 6.
4
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Cancer Res. 2008 Jul 1;68(13):5460-8. doi: 10.1158/0008-5472.CAN-08-0955.
5
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Curr Opin Cell Biol. 2006 Oct;18(5):516-23. doi: 10.1016/j.ceb.2006.08.011. Epub 2006 Aug 17.
6
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Mol Cell Biol. 2006 Jul;26(13):5155-67. doi: 10.1128/MCB.02186-05.
7
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Mol Cell Endocrinol. 2005 Dec 21;245(1-2):77-85. doi: 10.1016/j.mce.2005.10.008. Epub 2005 Nov 18.
8
Focal adhesion kinase: in command and control of cell motility.粘着斑激酶：细胞运动的指挥与控制者
Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. doi: 10.1038/nrm1549.
9
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10
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