小沉默 RNA：拼接病毒基因组。
Small Silencing RNAs: Piecing Together a Viral Genome.
机构信息
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, 6500 HB Nijmegen, The Netherlands.
出版信息
Cell Host Microbe. 2010 Feb 18;7(2):87-9. doi: 10.1016/j.chom.2010.02.001.
PMID:20159613
Abstract
Virus-derived small interfering RNAs (siRNAs) are the hallmark of RNAi-based antiviral immunity. Wu and colleagues demonstrate how viral genomes can be assembled from these small RNA sequences. Their results provide an approach for virus discovery as well as important insights into how these siRNAs mediate antiviral defense.
摘要
病毒来源的小干扰 RNA（siRNA）是 RNA 干扰抗病毒免疫的标志。Wu 及其同事展示了如何从这些小 RNA 序列组装病毒基因组。他们的研究结果为病毒发现提供了一种方法，同时也深入了解了这些 siRNA 如何介导抗病毒防御。
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