Li Qiu-hua, Quan Song, Chen Lei-ning, Li Hong, Gao Rui-hua, Ni Hao, Yu Min, Chen Si-mei, Luo Chen
Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):236-8.
To study the clinical factors affecting the outcomes of repeated assisted reproductive technology (ART) cycles.
A retrospective analysis of the clinical data and outcomes was conducted among 160 patients undergoing repeated IVF/ICSI-ET treatment between January 2006 and April 2009.
The patients with successful clinical pregnancy after two ART cycles (group A) had a younger age and shorter duration of infertility, and had more antral follicles (AFC), more eggs and good-quality embryos with more transferred embryos available and higher good-quality embryo rate (P<0.05) than those who failed to have pregnancy after the cycles (group B). In the second cycle, the patients in group A had higher doses of short-acting GnRHa, r-HCG and HMG and at the same time more good eggs and embryos than in the first cycle.
Female age is one of the most important factors affecting the pregnancy rate after repeated ART cycles. The clinical pregnancy rate can be enhanced by administering short-acting GnRHa, HMG, oral contraceptives and adjusting the dose of Gn as well as changing the culture medium of embryos.
研究影响重复辅助生殖技术（ART）周期结局的临床因素。
对2006年1月至2009年4月期间接受重复体外受精/卵胞浆内单精子注射-胚胎移植（IVF/ICSI-ET）治疗的160例患者的临床资料和结局进行回顾性分析。
经过两个ART周期后临床妊娠成功的患者（A组）比周期后未妊娠的患者（B组）年龄更小、不孕时间更短，窦卵泡（AFC）更多、获卵数更多、优质胚胎更多、可移植胚胎更多且优质胚胎率更高（P<0.05）。在第二个周期，A组患者使用短效促性腺激素释放激素激动剂（GnRHa）、重组人绒毛膜促性腺激素（r-HCG）和尿促性素（HMG）的剂量更高，同时优质卵子和胚胎比第一个周期更多。
女性年龄是影响重复ART周期后妊娠率的最重要因素之一。通过使用短效GnRHa、HMG、口服避孕药以及调整Gn剂量和改变胚胎培养基可提高临床妊娠率。
