Department of Neurology, University of Iowa Carver College of Medicine, USA.
J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):48-54. doi: 10.1176/jnp.2010.22.1.48.
The authors examined the long-term cognitive implications of cancer treatment among breast cancer survivors over 65 years old who received treatment during midlife. Thirty women survivors were matched with 30 noncancer, healthy older adults in terms of age, education, and IQ. The cancer survivors scored significantly lower in the cognitive domains of executive functioning, working memory, and divided attention, reflecting potential dysfunction in frontal-subcortical brain regions. Our findings suggest that among breast cancer survivors who remain disease-free for more than a decade, the previous cancer treatment may further augment cognitive dysfunction associated with age-related brain changes.
作者研究了中年时期接受治疗的 65 岁以上乳腺癌幸存者的长期认知影响。30 名女性幸存者在年龄、教育和智商方面与 30 名非癌症健康老年人相匹配。癌症幸存者在执行功能、工作记忆和注意力分散等认知领域的得分明显较低，反映出额叶-皮质下脑区潜在的功能障碍。我们的研究结果表明，在癌症无复发超过十年的乳腺癌幸存者中，先前的癌症治疗可能会进一步加剧与年龄相关的大脑变化相关的认知功能障碍。
