School of Clinical and Experimental Medicine, University of Birmingham, Birmingham Women's Foundation Trust, Edgbaston, Birmingham, UK.
Fetal Diagn Ther. 2010;27(3):171-3. doi: 10.1159/000284928. Epub 2010 Feb 16.
We present a case of transient abnormal myelopoiesis (TAM) presenting as non-immune fetal hydrops (NIHF). Hydrops fetalis (HF) is a condition associated with very high perinatal mortality, especially when no treatable cause, such as fetal anaemia, exists. In fetuses prior to 24 weeks with NIHF, a chromosomal anomaly is a common association. TAM is a leukaemic condition, almost entirely limited to children with Down syndrome. The presentation of TAM prenatally is unusual but cases may present ultrasonographically with NIHF and associated fetal hepatosplenomegaly. We report a case presenting in this manner with NIHF detected at 29 weeks' gestation and discuss the subsequent diagnosis and management of in utero TAM.
我们报告了一例表现为非免疫性胎儿水肿（NIHF）的短暂性髓系异常（TAM）病例。胎儿水肿（HF）是一种与围产期死亡率非常高相关的疾病，尤其是当不存在可治疗的原因，如胎儿贫血时。在 NIHF 的 24 周前胎儿中，染色体异常是一种常见的关联。TAM 是一种白血病，几乎完全局限于唐氏综合征患儿。TAM 产前表现不常见，但病例可能在超声检查中表现为 NIHF 和相关的胎儿肝脾肿大。我们报告了一例以这种方式表现的病例，在 29 周妊娠时发现 NIHF，并讨论了宫内 TAM 的随后诊断和治疗。
