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Differences underlying EGFR and HER2 oncogene addiction.

作者信息

Faber Anthony C, Wong Kwok-Kin, Engelman Jeffrey A

出版信息

Cell Cycle. 2010 Mar 1;9(5):851-2. doi: 10.4161/cc.9.5.11096. Epub 2010 Mar 30.

Abstract
摘要

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本文引用的文献

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19503-8. doi: 10.1073/pnas.0905056106. Epub 2009 Oct 22.
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Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Nat Rev Cancer. 2009 Aug;9(8):550-62. doi: 10.1038/nrc2664.
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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
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