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靶向 DARPin_9-29 的金纳米棒可选择性抑制小鼠体内 HER2 阳性肿瘤的生长。

DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice.

作者信息

Proshkina Galina M, Shramova Elena I, Shilova Marya V, Zelepukin Ivan V, Shipunova Victoria O, Ryabova Anastasia V, Deyev Sergey M, Kotlyar Alexander B

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St, 16/10, 117997 Moscow, Russia.

MEPhI (Moscow Engineering Physics Institute), Institute of Engineering Physics for Biomedicine (PhysBio), 31 Kashirskoe Shosse, 115409 Moscow, Russia.

出版信息

Cancers (Basel). 2021 Oct 19;13(20):5235. doi: 10.3390/cancers13205235.

DOI:10.3390/cancers13205235
PMID:34680384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8534065/
Abstract

Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

摘要

近红外光疗在癌症治疗方面具有巨大的治疗潜力。然而，为了实现高效应用，体内光热剂应在血液中表现出优异的稳定性，并能靶向递送至病理组织。在此，我们证明了与HER2特异性设计的锚蛋白重复蛋白DARPin_9-29偶联的稳定牛血清白蛋白包被的金纳米棒，可选择性地在小鼠HER2阳性异种移植肿瘤中积累，并在用近红外光照射时导致肿瘤大小显著减小。这些结果为新型基于DARPin的癌症靶向光热疗法的开发铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/41ee95489182/cancers-13-05235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/835e63953d29/cancers-13-05235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/e0052432e5d2/cancers-13-05235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/3a3af1940f5c/cancers-13-05235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/41ee95489182/cancers-13-05235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/835e63953d29/cancers-13-05235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/e0052432e5d2/cancers-13-05235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/3a3af1940f5c/cancers-13-05235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4749/8534065/41ee95489182/cancers-13-05235-g004.jpg

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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.工程化一种具有多种作用机制的抗 HER2 双价抗体。
Nat Commun. 2021 Jun 18;12(1):3790. doi: 10.1038/s41467-021-23948-6.
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Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape.
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