吲哚唑烷抑制去卵巢雌激素处理大鼠的高催乳素血症。

Idazoxan inhibits hyperprolactinaemia in ovariectomized estrogen-treated rats.

作者信息

Navarra P, Eechaute W, Preziosi P, Lacroix E

机构信息

Laboratory of Normal and Pathologic Physiology, State University of Ghent, Belgium.

出版信息

Horm Metab Res. 1991 Jan;23(1):22-4. doi: 10.1055/s-2007-1003602.

DOI:10.1055/s-2007-1003602

PMID:2016076

Abstract

The alpha 2-antagonist idazoxan (IDZ) has previously been shown to inhibit hyperprolactinaemia triggered by various stimuli such as lactation, stress, serotonergic agents and morphine (Preziosi, Martire, Navarra, Pistritto and Vacca 1989; Krulich, Jurcovicova and Le 1989). In this study, we investigated the PRL-lowering activity of IDZ in ovariectomized estrogen-treated (OET) rats; since a PRL surge usually occurs in normal cycling rats on the day of proestrus, the effect of IDZ on pulsatile PRL release in intact female rats was also studied. IDZ significantly lowered plasma PRL levels in OET rats; no elevated PRL values were observed in normal cycling rats, indicating that IDZ might inhibit PRL surges in these animals. It is concluded that IDZ is an effective PRL-lowering agent in a number of physiological and pharmacological hyperprolactinaemic models.

摘要

α2拮抗剂咪唑克生（IDZ）此前已被证明可抑制由各种刺激引发的高催乳素血症，如泌乳、应激、血清素能药物和吗啡（Preziosi、Martire、Navarra、Pistritto和Vacca，1989年；Krulich、Jurcovicova和Le，1989年）。在本研究中，我们研究了IDZ对去卵巢雌激素处理（OET）大鼠的催乳素降低活性；由于正常发情周期的大鼠在发情前期通常会出现催乳素激增，因此我们还研究了IDZ对完整雌性大鼠脉冲式催乳素释放的影响。IDZ显著降低了OET大鼠的血浆催乳素水平；在正常发情周期的大鼠中未观察到催乳素值升高，这表明IDZ可能抑制这些动物的催乳素激增。研究得出结论，在多种生理和药理学高催乳素血症模型中，IDZ是一种有效的催乳素降低剂。