评估肾移植排斥风险的非侵入性方法。
Noninvasive methods to assess the risk of kidney transplant rejection.
作者信息
Cravedi Paolo, Mannon Roslyn B
机构信息
Mario Negri Institute for Pharmacological Research, Bergamo, Italy, Tel.: +39 035 453 5405, ,
出版信息
Expert Rev Clin Immunol. 2009 Sep 1;5(5):535-546. doi: 10.1586/eci.09.36.
Abstract
In current clinical practice, immune reactivity of kidney transplant recipients is estimated by monitoring the levels of immunosuppressive drugs, and by functional and/or histological evaluation of the allograft. The availability of assays that could directly quantify the extent of the recipient's immune response towards the allograft would help clinicians to customize the prescription of immunosuppressive drugs to individual patients. Importantly, these assays might provide a more in-depth understanding of the complex mechanisms of acute rejection, chronic injury, and tolerance in organ transplantation, allowing the design of new and potentially more effective strategies for the minimization of immunosuppression, or even for the induction of immunological tolerance. The purpose of this review is to summarize results from recent studies in this field.
摘要
在当前的临床实践中，通过监测免疫抑制药物的水平以及对同种异体移植物进行功能和/或组织学评估来估计肾移植受者的免疫反应性。能够直接量化受者对同种异体移植物免疫反应程度的检测方法，将有助于临床医生为个体患者定制免疫抑制药物的处方。重要的是，这些检测方法可能会更深入地了解器官移植中急性排斥、慢性损伤和耐受的复杂机制，从而设计出新的、可能更有效的策略来尽量减少免疫抑制，甚至诱导免疫耐受。本综述的目的是总结该领域近期研究的结果。
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