靶向免疫治疗中的免疫调节吲哚胺 2,3 双加氧酶途径。
Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy.
机构信息
Immunotherapy Center & Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
出版信息
Immunotherapy. 2009 Jul;1(4):645-61. doi: 10.2217/IMT.09.21.
Abstract
Natural immune tolerance is a formidable barrier to successful immunotherapy to treat established cancers and chronic infections. Conversely, creating robust immune tolerance via immunotherapy is the major goal in treating autoimmune and allergic diseases, and enhancing survival of transplanted organs and tissues. In this review, we focus on a natural mechanism that creates local T-cell tolerance in many clinically relevant settings of chronic inflammation involving expression of the cytosolic enzyme indoleamine 2,3-dioxygenase (IDO) by specialized subsets of dendritic cells. IDO-expressing dendritic cells suppress antigen-specific T-cell responses directly, and induce bystander suppression by activating regulatory T cells. Thus, manipulating IDO is a promising strategy to treat a range of chronic inflammatory diseases.
摘要
天然免疫耐受是成功免疫治疗已建立的癌症和慢性感染的一个巨大障碍。相反，通过免疫治疗产生强大的免疫耐受是治疗自身免疫和过敏疾病、提高移植器官和组织存活率的主要目标。在这篇综述中，我们专注于一种天然机制，即在涉及细胞溶质酶吲哚胺 2,3-双加氧酶 (IDO) 由专门的树突状细胞亚群表达的许多与临床相关的慢性炎症情况下，在局部创建 T 细胞耐受。IDO 表达的树突状细胞直接抑制抗原特异性 T 细胞反应，并通过激活调节性 T 细胞诱导旁观者抑制。因此，操纵 IDO 是治疗一系列慢性炎症性疾病的一种很有前途的策略。
相似文献
1
Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy.靶向免疫治疗中的免疫调节吲哚胺 2,3 双加氧酶途径。
Immunotherapy. 2009 Jul;1(4):645-61. doi: 10.2217/IMT.09.21.
2
Indoleamine-2,3-dioxygenase modulation of allergic immune responses.吲哚胺-2,3-双加氧酶对过敏性免疫反应的调节作用。
Curr Allergy Asthma Rep. 2006 Feb;6(1):27-31. doi: 10.1007/s11882-006-0006-7.
3
The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy.色氨酸 2,3-双加氧酶（IDO）途径控制过敏。
Allergy. 2012 Jun;67(6):718-25. doi: 10.1111/j.1398-9995.2012.02830.x. Epub 2012 Apr 23.
4
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.表达吲哚胺 2,3-双加氧酶的白血病树突状细胞通过诱导强效 T 调节细胞来损害白血病特异性免疫反应。
Haematologica. 2010 Dec;95(12):2022-30. doi: 10.3324/haematol.2010.025924. Epub 2010 Aug 26.
5
IDO expressing dendritic cells suppress allograft rejection of small bowel transplantation in mice by expansion of Foxp3+ regulatory T cells.表达吲哚胺2,3-双加氧酶的树突状细胞通过扩增Foxp3+调节性T细胞抑制小鼠小肠移植的同种异体排斥反应。
Transpl Immunol. 2015 Oct;33(2):69-77. doi: 10.1016/j.trim.2015.05.003. Epub 2015 May 20.
6
T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase.表达吲哚胺2,3-双加氧酶的T细胞调节性浆细胞样树突状细胞
Handb Exp Pharmacol. 2009(188):165-96. doi: 10.1007/978-3-540-71029-5_8.
7
Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege.树突状细胞、吲哚胺 2,3-双加氧酶与获得性免疫豁免
Int Rev Immunol. 2010 Apr;29(2):133-55. doi: 10.3109/08830180903349669.
8
Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.吲哚胺2,3-双加氧酶阳性浆细胞样树突状细胞中的色氨酸分解代谢
Curr Drug Metab. 2007 Apr;8(3):209-16. doi: 10.2174/138920007780362581.
9
Induction of regulatory T Cells by dendritic cells through indoleamine 2,3-dioxygenase: a potent mechanism of acquired peripheral tolerance.树突状细胞通过吲哚胺 2,3-双加氧酶诱导调节性 T 细胞：获得性外周耐受的有效机制。
Curr Med Chem. 2011;18(15):2234-9. doi: 10.2174/092986711795656054.
10
Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.色氨酸 2,3-双加氧酶与树突状细胞的免疫耐受特性。
Immunol Invest. 2012;41(6-7):738-64. doi: 10.3109/08820139.2012.676122.
引用本文的文献
1
Recent advances in regulatory immune cells: exploring the world beyond Tregs.调节性免疫细胞的最新进展：探索Treg细胞之外的领域。
Front Immunol. 2025 May 16;16:1530301. doi: 10.3389/fimmu.2025.1530301. eCollection 2025.
2
Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC.IDO-1、PD-L1 和 MEK 的三重阻断作为 NSCLC 的潜在治疗策略。
J Transl Med. 2022 Nov 22;20(1):541. doi: 10.1186/s12967-022-03730-y.
3
Rocaglamide Prolonged Allograft Survival by Inhibiting Differentiation of Th1/Th17 Cells in Cardiac Transplantation.罗卡酰胺通过抑制心脏移植中 Th1/Th17 细胞的分化延长移植物存活期。
Oxid Med Cell Longev. 2022 Jan 17;2022:2048095. doi: 10.1155/2022/2048095. eCollection 2022.
4
[Allergic immunotherapy in children and adolescents].[儿童和青少年的变应性免疫疗法]
Rev Fr Allergol (2009). 2020 Oct-Nov;60(6):554-558. doi: 10.1016/j.reval.2020.07.003. Epub 2020 Sep 6.
5
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.免疫细胞和肿瘤微环境成像在免疫治疗新时代的相关性。
J Exp Clin Cancer Res. 2020 May 18;39(1):89. doi: 10.1186/s13046-020-01586-y.
6
Dendritic Cells Treated with Exogenous Indoleamine 2,3-Dioxygenase Maintain an Immature Phenotype and Suppress Antigen-specific T cell Proliferation.用外源性吲哚胺2,3-双加氧酶处理的树突状细胞维持未成熟表型并抑制抗原特异性T细胞增殖。
J Immunol Regen Med. 2019 Sep;5. doi: 10.1016/j.regen.2019.100015. Epub 2019 Feb 10.
7
Oral immunotherapy tolerizes mice to enzyme replacement therapy for Morquio A syndrome.口服免疫疗法使 Morquio A 综合征的小鼠对酶替代疗法产生耐受。
J Clin Invest. 2020 Mar 2;130(3):1288-1300. doi: 10.1172/JCI125607.
8
Cell based functional assays for IDO1 inhibitor screening and characterization.用于吲哚胺2,3-双加氧酶1（IDO1）抑制剂筛选和表征的基于细胞的功能测定。
Oncotarget. 2018 Jul 20;9(56):30814-30820. doi: 10.18632/oncotarget.25720.
9
Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design.变应原递呈抑制剂：通过基于结构的蛋白酶抑制剂设计靶向 1 组屋尘螨变应原哨兵先天免疫信号的理由。
Mol Pharmacol. 2018 Sep;94(3):1007-1030. doi: 10.1124/mol.118.112730. Epub 2018 Jul 5.
10
A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression.一种基于吲哚胺 2,3-双加氧酶表达的预测急性髓系白血病患者早期死亡率的新型免疫组织化学评分。
Sci Rep. 2017 Oct 16;7(1):12892. doi: 10.1038/s41598-017-12940-0.
本文引用的文献
1
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.联合NKT细胞激活与流感病毒疫苗接种可增强记忆性CTL的产生及保护性免疫。
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3330-5. doi: 10.1073/pnas.0813309106. Epub 2009 Feb 11.
2
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.细胞因子信号转导抑制因子3（SOCS3）驱动吲哚胺2,3-双加氧酶（IDO）的蛋白酶体降解，并拮抗IDO依赖性的免疫耐受形成。
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20828-33. doi: 10.1073/pnas.0810278105. Epub 2008 Dec 16.
3
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.促进肿瘤进展的慢性炎症通过诱导吲哚胺2,3-双加氧酶产生局部免疫抑制。
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17073-8. doi: 10.1073/pnas.0806173105. Epub 2008 Oct 24.
4
Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.前沿：自分泌转化生长因子-β由具有吲哚胺2,3-双加氧酶活性的树突状细胞维持默认的耐受性生成。
J Immunol. 2008 Oct 15;181(8):5194-8. doi: 10.4049/jimmunol.181.8.5194.
5
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.组蛋白去乙酰化酶抑制作用调节吲哚胺2,3-双加氧酶依赖的树突状细胞功能并调控小鼠实验性移植物抗宿主病。
J Clin Invest. 2008 Jul;118(7):2562-73. doi: 10.1172/JCI34712.
6
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.吲哚胺2,3-双加氧酶表达促进肾脏缺血再灌注损伤。
Am J Physiol Renal Physiol. 2008 Jul;295(1):F226-34. doi: 10.1152/ajprenal.00567.2007. Epub 2008 May 14.
7
Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior.给小鼠接种卡介苗会引发急性疾病行为发作，随后出现慢性抑郁样行为。
Brain Behav Immun. 2008 Oct;22(7):1087-1095. doi: 10.1016/j.bbi.2008.04.001. Epub 2008 May 13.
8
Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses.吲哚胺2,3-双加氧酶的基因递送通过塑造T细胞反应类型延长心脏同种异体移植的存活时间。
J Gene Med. 2008 Jul;10(7):754-61. doi: 10.1002/jgm.1201.
9
Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma.吲哚胺2,3-双加氧酶在肝细胞癌中的表达及预后作用
J Cancer Res Clin Oncol. 2008 Nov;134(11):1247-53. doi: 10.1007/s00432-008-0395-1. Epub 2008 Apr 26.
10
Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation.肺树突状细胞中的吲哚胺2,3-双加氧酶促进Th2反应和过敏性炎症。
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6690-5. doi: 10.1073/pnas.0708809105. Epub 2008 Apr 24.
Zotero 插件