发育性听力损失会破坏突触抑制：对听觉处理的影响。
Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing.
作者信息
Takesian Anne E, Kotak Vibhakar C, Sanes Dan H
机构信息
Center for Neural Science, New York, University, NY 10003, USA, Tel.: +1 212 998 3914, ,
出版信息
Future Neurol. 2009 May 1;4(3):331-349. doi: 10.2217/FNL.09.5.
Abstract
Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatomical and physiological alterations of inhibitory connections at several regions within the central auditory pathway following hearing loss. Such aberrant inhibitory synaptic function may be linked to deficits in encoding binaural and spectral cues. Understanding the cellular changes that occur at inhibitory synapses following hearing loss may provide specific loci that can be targeted to improve function.
摘要
发育过程中的听力损失会导致中枢缺陷，即使外周功能恢复后这些缺陷仍会持续存在。一类关键的缺陷是由于中枢抑制性突触的变化，这些突触在听觉处理的各个方面都起着基础性作用。本综述聚焦于听力损失后中枢听觉通路内几个区域抑制性连接的解剖学和生理学改变。这种异常的抑制性突触功能可能与双耳和频谱线索编码缺陷有关。了解听力损失后抑制性突触发生的细胞变化可能会提供可作为靶点以改善功能的特定位点。
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