丝裂霉素的合成研究：通过还原氨基环化反应构建四环核心结构。
Synthetic Studies Towards the Mitomycins: Construction of the Tetracyclic Core via a Reductive Aminocyclization Reaction.
作者信息
Gubler Daniel A, Williams Robert M
机构信息
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
Tetrahedron Lett. 2009 Jul 22;50(29):4265-4267. doi: 10.1016/j.tetlet.2009.05.004.
Abstract
The tetracyclic core of the mitomycin family of natural products has been formed in one step from an acyclic precursor via a reductive aminocyclization reaction. Additionally, the 8-membered benzazocine can be prepared without the need for prior activation of the aniline. Construction of a mitomycin K analogue lacking the C9a methoxy moiety is also reported herein.
摘要
天然产物丝裂霉素家族的四环核心已通过还原氨基环化反应从无环前体一步形成。此外，无需预先活化苯胺即可制备八元苯并氮杂环辛因。本文还报道了一种缺少C9a甲氧基部分的丝裂霉素K类似物的构建。
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