氯绿菌素、其七种发色团非对映异构体及关键类似物的评估
Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.
作者信息
Clark Ryan C, Lee Sang Yeul, Hwang Inkyu, Searcey Mark, Boger Dale L
机构信息
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Tetrahedron Lett. 2009 Jul 1;50(26):3151-3153. doi: 10.1016/j.tetlet.2009.01.081.
Abstract
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
摘要
对氯富辛及其七种发色团非对映异构体和关键类似物进行了抑制MDM2-p53结合的比较研究，结果表明，发色团而非简单的取代基对天然产物的性质有显著贡献，且这种贡献与其相对和绝对立体化学无关。
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3
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