Clark Ryan C, Lee Sang Yeul, Hwang Inkyu, Searcey Mark, Boger Dale L
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
Tetrahedron Lett. 2009 Jul 1;50(26):3151-3153. doi: 10.1016/j.tetlet.2009.01.081.
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
对氯富辛及其七种发色团非对映异构体和关键类似物进行了抑制MDM2-p53结合的比较研究，结果表明，发色团而非简单的取代基对天然产物的性质有显著贡献，且这种贡献与其相对和绝对立体化学无关。
