Whiteley H E
Department of Veterinary Pathobiology, University of Illinois, Urbana 61801.
Invest Ophthalmol Vis Sci. 1991 Apr;32(5):1492-8.
Retinal dysplasia is a failure in normal retinal development. The morphologic sequence of the dysplastic processes was examined in fetuses and neonates from dogs affected with an inherited form of retinal dysplasia. The dysplastic change has its onset at 45-50 days' gestation and is most prominent in the dorsal peripapillary retina. Morphologic characteristics of involved sensory retina include the focal loss of cell junctions forming the external limiting membrane, folding of the sensory retina, disorganized proliferation of neuroblasts in the retina and subretinal space, and formation of rosettes composed of multiple layers of neuroblasts. These morphologic changes suggest that there is an intrinsic abnormality of neural retinal differentiation.
视网膜发育异常是正常视网膜发育过程的失败。对患有遗传性视网膜发育异常的犬胎儿和新生儿的发育异常过程的形态学序列进行了检查。发育异常变化在妊娠45 - 50天时开始，在视乳头周围视网膜背侧最为明显。受累感觉视网膜的形态学特征包括形成外界膜的细胞连接的局灶性丧失、感觉视网膜的折叠、视网膜和视网膜下间隙中神经母细胞的无序增殖以及由多层神经母细胞组成的玫瑰花结的形成。这些形态学变化表明神经视网膜分化存在内在异常。
