Kiani Salma, Staples Richard J, Treves S Ted, Packard Alan B
Division of Nuclear Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115.
Polyhedron. 2009 Mar 12;28(4):775-781. doi: 10.1016/j.poly.2008.12.006.
As part of our on-going effort to develop (64)Cu-based radiopharmaceuticals for PET (positron emission tomography) imaging of multidrug resistance in cancer, we prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-Hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydro-furan-3-one oxime) and its Cu(II) and Ni(II) complexes. When the copper(II) complex was prepared from Cu(ClO(4))(2) in ethanol, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)(2) and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent. The Ni(II) complex is square pyramidal with the perchlorate counterion at the apex.
作为我们持续致力于开发用于癌症多药耐药性正电子发射断层扫描(PET)成像的基于(64)铜的放射性药物的一部分,我们制备了一种四甲基呋喃酮官能化的二亚胺二肟配体TMFPreH(TMFPreH = 4 - [3 - (4 - 羟基亚氨基 - 2,2,5,5 - 四甲基 - 二氢呋喃 - 3 - 亚基氨基) - 丙基亚氨基] - 2,2,5,5 - 四甲基 - 二氢呋喃 - 3 - 一肟)及其铜(II)和镍(II)配合物。当从乙醇中的Cu(ClO₄)₂制备铜(II)配合物时,它以铜(II)桥连二聚体形式分离出来,但当从Cu(OAc)₂制备并在丙酮中加热时,配体的丙酮加合物的一个不寻常例子是由溶剂还原其中一个亚胺双键形成的。镍(II)配合物是四方锥构型,高氯酸根抗衡离子位于顶点。