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Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease.

作者信息

Wadas Thaddeus J, Wong Edward H, Weisman Gary R, Anderson Carolyn J

机构信息

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus Box 8225 St. Louis, Missouri 63110, USA.

出版信息

Chem Rev. 2010 May 12;110(5):2858-902. doi: 10.1021/cr900325h.

DOI:10.1021/cr900325h
PMID:20415480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2874951/
Abstract
摘要
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Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides.用于生物分子放射性标记和金属放射性核素靶向递送的双功能偶联剂。
Adv Drug Deliv Rev. 2008 Sep;60(12):1347-70. doi: 10.1016/j.addr.2008.04.006. Epub 2008 Apr 23.
6
PET and SPECT imaging of a radiolabeled minigastrin analogue conjugated with DOTA, NOTA, and NODAGA and labeled with (64)Cu, (68)Ga, and (111)In.与DOTA、NOTA和NODAGA共轭并用(64)Cu、(68)Ga和(111)In标记的放射性标记小分子胃泌素类似物的正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）成像
Mol Pharm. 2014 Nov 3;11(11):3930-7. doi: 10.1021/mp500283k. Epub 2014 Jul 11.
7
Beyond 18F-FDG: Characterization of PET/CT and PET/MR Scanners for a Comprehensive Set of Positron Emitters of Growing Application--18F, 11C, 89Zr, 124I, 68Ga, and 90Y.超越 18F-FDG：用于日益广泛应用的一系列正电子发射体的 PET/CT 和 PET/MR 扫描仪的特性——18F、11C、89Zr、124I、68Ga 和 90Y。
J Nucl Med. 2015 Aug;56(8):1285-91. doi: 10.2967/jnumed.115.156711. Epub 2015 Jul 1.
8
Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides.评估一种1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸共轭铃蟾肽基放射性拮抗剂用于单光子发射计算机断层扫描、正电子发射断层扫描和治疗性放射性核素标记的情况。
Clin Cancer Res. 2009 Aug 15;15(16):5240-9. doi: 10.1158/1078-0432.CCR-08-3145. Epub 2009 Aug 11.
9
The production of [124I]iodine and [86Y]yttrium.[124I]碘和[86Y]镱的生产。
Eur J Nucl Med Mol Imaging. 2011 May;38 Suppl 1:S4-9. doi: 10.1007/s00259-011-1782-4. Epub 2011 Apr 12.
10
Selection of the optimal macrocyclic chelators for labeling with In and Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6.选择最佳的大环螯合剂用于标记 In 和 Ga，可提高使用工程支架蛋白 ADAPT6 进行 HER2 成像的对比度。
Eur J Pharm Biopharm. 2019 Jul;140:109-120. doi: 10.1016/j.ejpb.2019.05.008. Epub 2019 May 10.

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Nanoradiopharmaceuticals: Design Principles, Radiolabeling Strategies, and Biomedicine Applications.纳米放射性药物：设计原理、放射性标记策略及生物医学应用。
Pharmaceutics. 2025 Jul 14;17(7):912. doi: 10.3390/pharmaceutics17070912.
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Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression.选择用于用镓-68标记DARPin Ec1以进行EpCAM表达的PET成像的最佳螯合剂。
EJNMMI Radiopharm Chem. 2025 May 30;10(1):26. doi: 10.1186/s41181-025-00347-6.
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Development of Pd-Loaded Hf-Based Metal-Organic Framework as a Dual-Modal Contrast Agent for Photoacoustic Imaging and Computed Tomography.负载钯的铪基金属有机框架作为用于光声成像和计算机断层扫描的双模态造影剂的开发。
ACS Biomater Sci Eng. 2025 Jun 9;11(6):3634-3648. doi: 10.1021/acsbiomaterials.5c00169. Epub 2025 May 6.
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Intracellular Protein Binding of Zr-89 Oxine Cell Labeling for PET Cell Tracking Studies.用于PET细胞追踪研究的Zr-89 奥克辛细胞标记的细胞内蛋白质结合
Pharmaceutics. 2025 Apr 15;17(4):518. doi: 10.3390/pharmaceutics17040518.
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Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles.追踪技术的进展：绘制间充质干细胞衍生细胞外囊泡的轨迹
Chem Biomed Imaging. 2025 Feb 2;3(3):137-168. doi: 10.1021/cbmi.4c00085. eCollection 2025 Mar 24.
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Selective inhibition of NikA mediated Ni(II) import in E. coli by the Indium(III)-EDTA complex.铟（III）-乙二胺四乙酸络合物对大肠杆菌中NikA介导的镍（II）导入的选择性抑制作用。
Metallomics. 2025 Mar 28;17(4). doi: 10.1093/mtomcs/mfaf008.
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Evaluation of [F]AlF NOTA-5G, an Aluminum [F]fluoride Labeled Peptide Targeting the Cell Surface Receptor Integrin Alpha(v)beta(6) for PET Imaging.用于正电子发射断层显像（PET）成像的靶向细胞表面受体整合素α(v)β(6)的铝[F]氟化物标记肽[F]AlF NOTA-5G的评估。
Mol Imaging Biol. 2025 Apr;27(2):285-292. doi: 10.1007/s11307-025-01989-3. Epub 2025 Feb 20.
8
Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha.冷冻电子显微镜揭示了一种在成纤维细胞活化蛋白α上具有独特结合表位的单域抗体。
RSC Chem Biol. 2025 Feb 6;6(5):780-787. doi: 10.1039/d4cb00267a. eCollection 2025 May 8.
9
Radiocopper in Radiopharmacy and Medical Use: Current Status and Perspective.放射性药物学与医学应用中的放射性铜：现状与展望
J Med Chem. 2025 Feb 13;68(3):2356-2376. doi: 10.1021/acs.jmedchem.4c02885. Epub 2025 Feb 2.
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Recent Breakthroughs in PET-CT Multimodality Imaging: Innovations and Clinical Impact.PET-CT多模态成像的最新突破：创新与临床影响。
Bioengineering (Basel). 2024 Nov 30;11(12):1213. doi: 10.3390/bioengineering11121213.

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Triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic Acid (TTHA) and TTHA-Bis(butanamide) as Chelating Agents Relevant to Radiopharmaceutical Applications.三亚乙基四胺 - N，N，N'，N''，N'''，N'''- 六乙酸（TTHA）和TTHA - 双（丁酰胺）作为与放射性药物应用相关的螯合剂
Inorg Chem. 1998 Dec 14;37(25):6552. doi: 10.1021/ic981268i.
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(18)F, (64)Cu, and (68)Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer.(18)F、(64)Cu 和 (68)Ga 标记的 RGD- bombesin 异二聚体肽用于乳腺癌的 PET 成像。
Bioconjug Chem. 2009 May 20;20(5):1016-25. doi: 10.1021/bc9000245.
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Synthesis and Characterization of a Tetramethyl Furanone Functionalized Diiminedioxime, A Potential Ligand for Cu Radiopharmaceuticals, and its Copper(II) and Nickel(II) Complexes.一种四甲基呋喃酮官能化二亚胺二肟的合成与表征，铜放射性药物的潜在配体及其铜（II）和镍（II）配合物
Polyhedron. 2009 Mar 12;28(4):775-781. doi: 10.1016/j.poly.2008.12.006.
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True radiotracers: Cu-64 targeting vectors based upon bombesin peptide.真正的放射性示踪剂：基于蛙皮素肽的铜-64靶向载体。
Nucl Med Biol. 2009 Aug;36(6):579-85. doi: 10.1016/j.nucmedbio.2009.03.007.
5
Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agents.大环二酰胺配体体系：基于64Cu和68Ga的正电子发射断层显像剂的潜在螯合剂
Inorg Chem. 2009 Aug 3;48(15):7117-26. doi: 10.1021/ic900307f.
6
A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides.一种用于铜放射性药物的新型双功能螯合剂：一种带有羧基官能团以与肽偶联的笼状胺配体。
Chem Commun (Camb). 2009 Jun 14(22):3237-9. doi: 10.1039/b903426a. Epub 2009 Apr 23.
7
Synthesis of a novel bifunctional chelator AmBaSar based on sarcophagine for peptide conjugation and (64)Cu radiolabelling.基于肌氨酸的新型双功能螯合剂AmBaSar的合成，用于肽偶联和（64）铜放射性标记。
Dalton Trans. 2009 Jul 21(27):5395-400. doi: 10.1039/b902210d. Epub 2009 May 22.
8
Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET).利用铜-64放射性药物和正电子发射断层扫描（PET）对癌症进行分子成像。
Acc Chem Res. 2009 Jul 21;42(7):832-41. doi: 10.1021/ar800255q.
9
In vitro human leukocyte labeling with (64)Cu: an intraindividual comparison with (111)In-oxine and (18)F-FDG.用（64）铜进行体外人白细胞标记：与（111）铟-奥曲肽和（18）氟-脱氧葡萄糖的个体内比较。
Nucl Med Biol. 2009 Jul;36(5):545-9. doi: 10.1016/j.nucmedbio.2009.03.001. Epub 2009 May 7.
10
Novel imaging provides new insights into mechanisms of oxygen transport in tumors.新型成像技术为肿瘤中氧运输机制提供了新见解。
Curr Mol Med. 2009 May;9(4):435-41. doi: 10.2174/156652409788167122.