用于结核分枝杆菌转肽酶分析的标记美罗培南的合成。
Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases.
作者信息
Kastrinsky David B, Barry Clifton E
机构信息
The National Institutes of Health, National Institute of Allergy and Infectous Diseases, Tuberculosis Research Section, Bethesda MD 20892.
出版信息
Tetrahedron Lett. 2010;51(1):197-200. doi: 10.1016/j.tetlet.2009.10.124.
Abstract
A concise synthesis of (14)C labeled meropenem prepared from (14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies.
摘要
描述了一种由盐酸[¹⁴C]二甲胺制备的[¹⁴C]标记美罗培南的简洁合成方法。使用类似的反应序列，美罗培南核心也与生物素相连，从而提供了一种用于蛋白质相互作用研究的探针。
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