Oohira A, Zee D S, Guyton D L
Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Invest Ophthalmol Vis Sci. 1991 Apr;32(5):1693-703.
A 12-yr-old anisometropic patient had worn corrective eyeglasses (right eye, -0.50 +1.50 x 125; LE, -9.75 +2.50 x 60) for 7 yr, and then changed to contact lenses. Eye movements were recorded before and after the change to contact lenses using binocular search coils. In habitual spectacle viewing, the patient showed disconjugate adaptation. During monocular viewing, for example, ocular alignment changed by as much as 4 degrees during a 20 degrees saccade. Also, during monocular viewing, with either eye, placing the spectacle lens in front of the eye caused an increase in the disconjugate adaptive response compared with viewing without lenses. This finding emphasizes the context specificity of adaptive responses. After switching to contact lenses, the patient still wore his spectacles for 20-40 min each day. Although there was little residual disconjugate adaptation for vertical saccades, he showed considerable adaptation for horizontal saccades, especially for gaze changes that required divergence. The persistence of a partial state of disconjugate adaptation allowed the patient to use immediate, disparity-induced, horizontal vergence to aid ocular alignment in either the contact-lens-viewing or the spectacle-viewing condition. A more complete reversion to conjugacy occurred after nine days of exclusive use of his contact lenses. Then, in a short-term experiment, two minutes of binocular viewing through the eyeglasses induced a considerable reversion toward the previous state of disconjugate adaptation (up to 1.25 degrees of vergence change during monocular viewing). Finally, the waveform of the adapted (to spectacles) intrasaccadic vergence change with monocular viewing was similar to the waveform of the unadapted intrasaccadic vergence change during binocular refixations between targets that required a combined saccade and vergence. This finding suggests a common mechanism for adaptation to spectacle-corrected anisometropia and for normal binocular vergence-saccade interactions.
一名12岁的屈光参差患者佩戴矫正眼镜（右眼，-0.50 +1.50×125；左眼，-9.75 +2.50×60）7年，之后改戴隐形眼镜。在改戴隐形眼镜前后，使用双眼搜索线圈记录眼球运动。在习惯性佩戴眼镜视物时，该患者表现出非共轭适应性。例如，在单眼视物时，20度扫视过程中眼位对齐变化多达4度。此外，在单眼视物时，无论用哪只眼睛，将眼镜片置于眼前与不戴眼镜视物相比，非共轭适应性反应都会增加。这一发现强调了适应性反应的情境特异性。改戴隐形眼镜后，该患者仍每天佩戴眼镜20 - 40分钟。尽管垂直扫视几乎没有残留的非共轭适应性，但他在水平扫视方面表现出相当程度的适应性，尤其是在需要散开的注视变化时。非共轭适应部分状态的持续存在使患者能够在佩戴隐形眼镜或眼镜视物时，利用即时的、视差诱导的水平聚散来辅助眼位对齐。在仅使用隐形眼镜九天后，出现了更完全的共轭恢复。然后，在一项短期实验中，通过眼镜进行两分钟的双眼视物会导致向先前非共轭适应状态的显著恢复（单眼视物时聚散变化高达1.25度）。最后，单眼视物时适应（于眼镜）的扫视内聚散变化波形与在需要联合扫视和聚散的目标之间双眼重新注视时未适应的扫视内聚散变化波形相似。这一发现表明，适应眼镜矫正的屈光参差和正常双眼聚散 - 扫视相互作用存在共同机制。
