迈向具有抗肿瘤活性的反式铂化合物
Towards Antitumor Active trans-Platinum Compounds.
作者信息
Aris Sheena M, Farrell Nicholas P
机构信息
Department of Chemistry, Virginia Commonwealth University 1001 W. Main St., Richmond VA 23284-2006.
出版信息
Eur J Inorg Chem. 2009 Apr 1;2009(10):1293. doi: 10.1002/ejic.200801118.
Abstract
Substitution of NH(3) by a range of amines in trans-[PtCl(2)(NH(3))(2)] produces compounds with cytotoxicity significantly improved over the parent transplatin and in many cases equivalent to that of cisplatin. This microreview summarizes the chemistry and biology of trans-platinum compounds containing principally planar amines and succinctly reviews the current status of anticancer relevance of the trans-platinum geometry. The nature of bifunctional DNA adducts (intrastrand, interstrand) is remarkably dependent on the nature of the amine. Further, the stability of monofunctional adducts allows for competitive production of DNA-protein crosslinks and overall the results suggest that the trans-platinum chemotype may offer significant potential for design of selective DNA-protein crosslinking agents. A subset of proteins known to bind to DNA modified by trans-platinum is that comprised of zinc fingers - model studies show the potential for formation of heteronuclear thiolate-bridged species as precedent for zinc displacement from the biomolecule.
摘要
在反式-[PtCl₂(NH₃)₂]中用一系列胺取代NH₃会生成细胞毒性比母体反式铂显著提高且在许多情况下与顺铂相当的化合物。本微型综述总结了主要含平面胺的反式铂化合物的化学和生物学性质，并简要回顾了反式铂几何结构在抗癌相关性方面的现状。双功能DNA加合物（链内、链间）的性质显著依赖于胺的性质。此外，单功能加合物的稳定性使得DNA-蛋白质交联能够竞争性产生，总体结果表明反式铂化学类型可能为设计选择性DNA-蛋白质交联剂提供巨大潜力。已知与经反式铂修饰的DNA结合的一类蛋白质是由锌指蛋白组成——模型研究表明形成异核硫醇盐桥连物种的可能性，这是锌从生物分子中被取代的先例。
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