一种铂-菲咯啉配合物对人端粒四链体DNA的稳定作用及对端粒酶的抑制作用
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.
作者信息
Reed Julie E, Neidle Stephen, Vilar Ramon
机构信息
Department of Chemistry, Imperial College London, London, UK SW7 2AZ.
出版信息
Chem Commun (Camb). 2007 Nov 14(42):4366-8. doi: 10.1039/b709898g. Epub 2007 Aug 13.
DOI:10.1039/b709898g
PMID:17957288
Abstract
Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.
摘要
已制备出两种新型单取代菲咯啉配体及其平面正方形铂（II）配合物；其中一种配合物已被证明可高度稳定四链体DNA并抑制端粒酶。
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