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一氧化氮驱动的逆行信号在恐惧记忆巩固中的作用。

A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory.

作者信息

Overeem Kathie A, Ota Kristie T, Monsey Melissa S, Ploski Jonathan E, Schafe Glenn E

机构信息

Department of Psychology, Yale University New Haven, CT, USA.

出版信息

Front Behav Neurosci. 2010 Feb 5;4:2. doi: 10.3389/neuro.08.002.2010. eCollection 2010.

DOI:10.3389/neuro.08.002.2010
PMID:20161806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2820379/
Abstract

In both invertebrate and vertebrate models of synaptic plasticity, signaling via the putative "retrograde messenger" nitric oxide (NO) has been hypothesized to serve as a critical link between functional and structural alterations at pre- and postsynaptic sites. However, while in vitro models of synaptic plasticity have consistently implicated NO signaling in linking postsynaptic induction mechanisms with accompanying presynaptic changes, a convincing role of such "retrograde signaling" in mammalian memory formation has remained elusive. Using auditory Pavlovian fear conditioning, we show that synaptic plasticity and NO signaling in the lateral nucleus of the amygdala (LA) regulate the expression of the ERK-driven immediate early gene early growth response gene I (EGR-1) in regions of the auditory thalamus that are presynaptic to the LA. Further, antisense knockdown of EGR-1 in the auditory thalamus impairs both fear memory consolidation and the training-induced elevation of two presynaptically localized proteins in the LA. These findings indicate that synaptic plasticity and NO signaling in the LA during auditory fear conditioning promote alterations in ERK-driven gene expression in auditory thalamic neurons that are required for both fear memory consolidation as well as presynaptic correlates of fear memory formation in the LA, and provide general support for a role of NO as a "retrograde signal" in mammalian memory formation.

摘要

在突触可塑性的无脊椎动物和脊椎动物模型中，通过假定的“逆行信使”一氧化氮（NO）进行的信号传导被认为是突触前和突触后部位功能和结构改变之间的关键联系。然而，虽然突触可塑性的体外模型一直表明NO信号传导在将突触后诱导机制与伴随的突触前变化联系起来，但这种“逆行信号传导”在哺乳动物记忆形成中的令人信服的作用仍然难以捉摸。利用听觉巴甫洛夫条件性恐惧实验，我们发现杏仁核外侧核（LA）中的突触可塑性和NO信号传导调节听觉丘脑区域中ERK驱动的立即早期基因早期生长反应基因I（EGR-1）的表达，该区域是LA的突触前区域。此外，在听觉丘脑中反义敲低EGR-1会损害恐惧记忆巩固以及LA中两种突触前定位蛋白的训练诱导升高。这些发现表明，听觉恐惧条件反射期间LA中的突触可塑性和NO信号传导促进了听觉丘脑神经元中ERK驱动的基因表达变化，这对于恐惧记忆巩固以及LA中恐惧记忆形成的突触前相关因素都是必需的，并为NO作为哺乳动物记忆形成中的“逆行信号”的作用提供了普遍支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/2a8bc5c7c926/fnbeh-04-002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/8f0aacf7741d/fnbeh-04-002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/48f0625902bb/fnbeh-04-002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/030f61d8f258/fnbeh-04-002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/a06a72a9e796/fnbeh-04-002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/887b6f395338/fnbeh-04-002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/015e986387a6/fnbeh-04-002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/2a8bc5c7c926/fnbeh-04-002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/8f0aacf7741d/fnbeh-04-002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/48f0625902bb/fnbeh-04-002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/030f61d8f258/fnbeh-04-002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/a06a72a9e796/fnbeh-04-002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/887b6f395338/fnbeh-04-002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/015e986387a6/fnbeh-04-002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/160a/2820379/2a8bc5c7c926/fnbeh-04-002-g007.jpg

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2
Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear.增加听觉丘脑的CREB可增强听觉条件性恐惧的记忆和泛化。
Learn Mem. 2008 May 30;15(6):443-53. doi: 10.1101/lm.993608. Print 2008 Jun.
3
Auditory specific fear conditioning results in increased levels of synaptophysin in the basolateral amygdala.
Front Syst Neurosci. 2013 Mar 26;7:5. doi: 10.3389/fnsys.2013.00005. eCollection 2013.
4
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Cell. 2011 Oct 28;147(3):509-24. doi: 10.1016/j.cell.2011.10.009.
5
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Neural Plast. 2010;2010:540940. doi: 10.1155/2010/540940. Epub 2011 Feb 20.
6
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7
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8
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9
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5
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EMBO J. 2006 Sep 20;25(18):4361-71. doi: 10.1038/sj.emboj.7601318. Epub 2006 Sep 7.
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8
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9
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