Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery of Mexico, Delegación Tlalpan, Ciudad de méxico, Distrito Federal, Mexico.
Neurochem Res. 2010 Oct;35(10):1659-65. doi: 10.1007/s11064-010-0227-y. Epub 2010 Aug 1.
The neurochemical basis of aggressive behavior in humans is not fully understood. In this study we explored the relationship between aggressiveness (as measured by the Overt Aggression Scale), cognitive performance (as measured by the Mini Mental State Examination), and biochemical markers of dopamine neurotransmission (homovanillic acid, HVA) and nitric oxide synthesis (nitrite plus nitrate, NO(x)) in cerebrospinal fluid from 70 patients with acute brain disorders, mainly brain infections. Aggressive behavior and cognitive performance showed an inverse correlation. NO(x)/HVA ratio was inversely correlated to aggressive behavior, and positively correlated to cognitive performance. A subanalysis with antipsychotic-naïve patients confirmed those results. The balance between nitric oxide and dopamine could be related to the cognitive control of aggressive impulse.
人类攻击行为的神经化学基础尚未完全阐明。本研究旨在探讨 70 例急性脑部疾病（主要为脑部感染）患者的脑脊液中多巴胺神经递质生物标志物（高香草酸，HVA）和一氧化氮合成物（亚硝酸盐/硝酸盐，NOx）与攻击性（采用外显攻击量表进行测量）和认知功能（采用简易精神状态检查进行测量）之间的关系。攻击性和认知功能呈负相关。NOx/HVA 比值与攻击性呈负相关，与认知功能呈正相关。对未经抗精神病药物治疗的患者进行的亚组分析证实了上述结果。一氧化氮和多巴胺之间的平衡可能与攻击冲动的认知控制有关。
