ERK 在学习和记忆中的作用：研究进展综述。
ERK in learning and memory: a review of recent research.
机构信息
Department of Anesthesiology, Affiliated No.4 Hospital of Soochow University, Wuxi, 214062, China.
出版信息
Int J Mol Sci. 2010 Jan 13;11(1):222-232. doi: 10.3390/ijms11010222.
Abstract
The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-activated protein kinase (MAPK) superfamily, which is an important, highly conserved family of enzymes associated with cell membrane receptors and regulative targets. In the central nervous system, there is almost no mature neuronal proliferation and differentiation, but the regulation of MAPK and its upstream and downstream molecular pathways is still widespread, with the ERK signaling pathway being one of the most actively studied signal transduction pathways. It is activated by a variety of cell growth factors and substances which promote mitotic activity, and transmits extracellular signals from the cell surface to the nucleus, which transmission plays an important role in the process of cell proliferation and differentiation. In recent years, accumulating evidence has shown that the ERK signaling pathway has an important link with the higher functions of learning and memory.
摘要
细胞外信号调节激酶（ERK）通路是丝裂原活化蛋白激酶（MAPK）超家族的成员，MAPK 超家族是与细胞膜受体和调节靶标相关的重要高度保守的酶家族。在中枢神经系统中，几乎没有成熟的神经元增殖和分化，但 MAPK 及其上下游分子途径的调节仍然广泛存在，ERK 信号通路是研究最为活跃的信号转导通路之一。它被多种促进有丝分裂活性的细胞生长因子和物质激活，并将细胞表面的胞外信号传递到细胞核内，这种传递在细胞增殖和分化过程中发挥着重要作用。近年来，越来越多的证据表明 ERK 信号通路与学习和记忆的高级功能有重要联系。
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