Institute of Nutrition and Health, Qingdao University, Qingdao 266071, China.
School of Public Health, Qingdao University, Qingdao 266071, China.
Nutrients. 2024 Aug 10;16(16):2641. doi: 10.3390/nu16162641.
Lard is highly appreciated for its flavor. However, it has not been elucidated how to consume lard while at the same time eliminating its adverse effects on postpartum cognitive function. Female mice were divided into three groups ( = 10): soybean oil (SO), lard oil (LO), and a mixture of soybean oil and lard at a ratio of 1:1 (LS). No significant difference was observed between the SO and LS groups in behavioral testing of the maternal mice, but the LO group was significantly worse compared with these two groups. Moreover, the SO and LS supplementation increased docosahexaenoic acid (DHA) and total -3 polyunsaturated fatty acid (PUFA) levels in the brain and short-chain fatty acid (SCFA)-producing bacteria in feces, thereby mitigating neuroinflammation and lowering the p-ERK(1/2)/ERK(1/2), p-CREB/CREB, and BDNF levels in the brain compared to the LO group. Collectively, the LS group inhibited postpartum cognitive impairment by regulating the brain fatty acid composition, neuroinflammation, gut microbiota, and the SCFA/ERK(1/2)/CREB/BDNF signaling pathway compared to lard.
猪油因其风味而备受推崇。然而，目前尚不清楚如何在消除猪油对产后认知功能的不利影响的同时消费猪油。将雌性小鼠分为三组（每组 10 只）：大豆油（SO）、猪油（LO）和大豆油与猪油按 1:1 的比例混合（LS）。在母鼠的行为测试中，SO 和 LS 组之间没有观察到显著差异，但 LO 组与这两组相比明显较差。此外，SO 和 LS 补充剂增加了大脑中的二十二碳六烯酸（DHA）和总 -3 多不饱和脂肪酸（PUFA）水平以及粪便中产生短链脂肪酸（SCFA）的细菌，从而减轻了神经炎症，并降低了 LO 组大脑中的 p-ERK(1/2)/ERK(1/2)、p-CREB/CREB 和 BDNF 水平。总的来说，与猪油相比，LS 组通过调节大脑脂肪酸组成、神经炎症、肠道微生物群和 SCFA/ERK(1/2)/CREB/BDNF 信号通路抑制了产后认知障碍。
