黑柿树根提取物的抗惊厥活性。
Anticonvulsant activity of Diospyros fischeri root extracts.
作者信息
Moshi Mainen J, Mbwambo Zakaria H, Nondo Ramadhani S O, Masimba Pax J, Kapingu Modest C, Magelewanya Edward S
机构信息
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, P.O.Box 65001, Dar es Salaam, Tanzania.
出版信息
Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):226-30.
Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature.
柿属植物费氏柿（柿科）在传统医学中用于治疗癫痫。根部的二氯甲烷、乙酸乙酯和乙醇提取物，剂量在100至1600毫克/千克体重之间，以剂量依赖性方式抑制由A型γ-氨基丁酸（GABAa）受体拮抗剂戊四氮（PTZ）诱发的惊厥。这些提取物对卤虫也表现出低毒性，LC（50）值在45.4至95.4微克/毫升之间。这些结果为费氏柿提取物治疗失神性癫痫的潜力提供了证据，特别是考虑到它们看似无害的性质。
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