姜黄素类对小鼠被动皮肤过敏反应和搔抓行为的抑制作用。
Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice.
机构信息
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul, 130-701, Korea.
出版信息
Arch Pharm Res. 2009 Dec;32(12):1783-7. doi: 10.1007/s12272-009-2217-7. Epub 2010 Feb 17.
To understand anti-allergic effect of Curcuma aromatica (family Zingerberaceae), which inhibited passive cutenous anaphylaxis (PCA) reaction in preliminary study, we isolated its main constituents, curcumin, demethoxycurcumin and bisdemethoxycurcumin, and investigated their inhibitory effects against PCA reaction and scratching behavior. These curcuminoids inhibited the PCA reaction induced by the IgE-antigen complex (IAC) and the scratching behavior induced by compound 48/80. These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and IL-4, and transcription factor NF-kappaB activation in IAC-induced RBL-2H3 cells. Of these curcuminoids, curcumin exhibited the most potent inhibition, followed by demethoxycurcumin and bisdemethoxycurcumin. These findings suggest that curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching.
为了了解姜黄（姜科）的抗过敏作用，该研究初步抑制了被动皮肤过敏反应（PCA），我们分离了其主要成分姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素，并研究了它们对 PCA 反应和搔抓行为的抑制作用。这些姜黄素抑制了 IgE-抗原复合物（IAC）诱导的 PCA 反应和化合物 48/80 诱导的搔抓行为。这些姜黄素还抑制了 IAC 诱导的 RBL-2H3 细胞脱颗粒、TNF-α和 IL-4 的蛋白表达以及转录因子 NF-κB 的激活。在这些姜黄素中，姜黄素表现出最强的抑制作用，其次是脱甲氧基姜黄素和双脱甲氧基姜黄素。这些发现表明，姜黄素类化合物，特别是姜黄素，可以改善过敏疾病的症状，如过敏反应和瘙痒。
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