Dobbels P, Van Overbeke L, Vanbeckevoort D, Hiele M
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
Acta Gastroenterol Belg. 2009 Oct-Dec;72(4):455-7.
During the last 5 years we identified 7 patients with a history of episodic acute abdominal pain and subobstruction due to intestinal angioedema secondary to the use of Angiotensin Converting Enzyme (ACE) inhibitors. These cases were all diagnosed in one gastroenterology department. This is thereby the largest single centre case series of ACE inhibitor-induced angioedema that has been published until now. Our findings suggest that this syndrome is far more frequent than international literature would let us believe. We also describe one of the first male cases diagnosed with this entity for which there is a significant female predominance. In the presence of an appropriate history and suggestive findings on CT scan, this diagnosis can relatively easily be made if one is sufficiently intent on it. An appropriate diagnosis can save these patients a lot of unnecessary diagnostic procedures and discomfort.
在过去5年中，我们确诊了7例有发作性急性腹痛病史且因使用血管紧张素转换酶（ACE）抑制剂继发肠道血管性水肿而出现不全梗阻的患者。这些病例均在同一个胃肠病科确诊。因此，这是迄今为止已发表的关于ACE抑制剂诱发血管性水肿的最大单中心病例系列。我们的研究结果表明，这种综合征比国际文献让我们认为的更为常见。我们还描述了首例被诊断为此病的男性病例，此前该病明显以女性为主。如果有合适的病史且CT扫描有提示性表现，只要足够重视，相对容易做出该诊断。正确的诊断可为这些患者省去许多不必要的诊断程序和不适。
