Daptomycin: pharmacology and clinical use.

IMPORTANCE OF THE FIELD

Infections caused by Gram-positive organisms have increased in frequency and severity. Daptomycin offers a therapeutic option in an era of increasing resistance.

AREAS COVERED IN THIS REVIEW

Literature from 1986 to present was reviewed for pharmacological, preclinical and clinical studies on daptomycin.

WHAT THE READER WILL GAIN

The pharmacological properties, resistance mechanisms and clinical applications of daptomycin are discussed. Recommendations are offered on the use of this agent for the treatment of resistant Gram-positive infections.

TAKE HOME MESSAGE

Daptomycin is a reliable agent for the treatment of Gram-positive infections. It has been shown to be effective in bacteremia and endocarditis, as well as in soft-tissue infections caused by Gram-positive organisms. Its role in the treatment of bone and joint infections is not well-defined. Resistance is currently uncommon in clinical isolates. However, emergence of resistance during therapy is a concern. This may be prevented by use of higher doses.