Department of Pediatrics, Warren Alpert Medical School of Brown University, Women and Infants' Hospital of Rhode Island, Providence, RI 02905, USA.
Am J Reprod Immunol. 2010 Jun;63(6):482-91. doi: 10.1111/j.1600-0897.2010.00810.x. Epub 2010 Feb 16.
It is widely accepted that pregnancy constitutes a unique developmental event. Unprecedented intrauterine actions of angiogenesis, immunity, and neuroendocrine regulation are juxtaposed to mechanisms of senescence that enable fetal growth and protection. The suppressive and regulatory factors that facilitate healthy pregnancy are under investigation. In non-pregnant systems of infection and inflammation, the cytokine interleukin-10 (IL-10) has been widely investigated because of its potential as a key immunosuppressant in response to a multitude of inflammatory events. In the context of pregnancy, IL-10 levels increase markedly in women during early pregnancy and remain elevated well into the third trimester immediately prior to onset of labor. The role of IL-10 during pregnancy as a suppressor of active maternal immunity to allow acceptance of the fetal allograft has been a point of study. Moreover, secretion of IL-10 by a diverse set of maternal and fetal cells has proven to aid in the orchestration of normal processes of pregnancy. Interestingly, some of the more profound findings regarding the actions of IL-10 during pregnancy have manifested from research that focuses on aberrant pregnancy outcomes as a result of inflammation, hormonal imbalances, or gene-environment interactions. This review focuses on the role of IL-10 as a facilitator of successful pregnancy both as an immune suppressive agent and a mediator of cross talk between the placenta and the decidua. Importantly, we discuss investigations on adverse pregnancy conditions to further elucidate the multifarious role of IL-10 at the maternal-fetal interface.
人们普遍认为，妊娠是一个独特的发育事件。前所未有的血管生成、免疫和神经内分泌调节作用与衰老机制并列，使胎儿能够生长和得到保护。正在研究促进健康妊娠的抑制和调节因子。在非妊娠的感染和炎症系统中，细胞因子白细胞介素-10（IL-10）因其作为对多种炎症事件的关键免疫抑制剂的潜力而得到广泛研究。在妊娠的背景下，IL-10 水平在妊娠早期的妇女中明显升高，并在分娩前的第三个妊娠期末期持续升高。IL-10 在妊娠期间作为抑制母体主动免疫以允许接受胎儿同种异体移植物的作用一直是研究的重点。此外，多种母体和胎儿细胞分泌的 IL-10 已被证明有助于正常妊娠过程的协调。有趣的是，一些关于 IL-10 在妊娠期间作用的更深刻的发现来自于研究，这些研究集中在炎症、激素失衡或基因-环境相互作用导致的异常妊娠结局上。这篇综述重点讨论了 IL-10 作为成功妊娠的促进因子的作用，既是免疫抑制剂，又是胎盘和蜕膜之间相互作用的介质。重要的是，我们讨论了对不良妊娠情况的研究，以进一步阐明 IL-10 在母体-胎儿界面的多种作用。
