Huang Yiyao, Fang Ruijie, Xiong Ting, Li Wei, Yu Nan
Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Microorganisms. 2025 May 4;13(5):1073. doi: 10.3390/microorganisms13051073.
Recently, the gut microbiota has been found to be associated with multiple organs and systems in the human body, playing a key role in the occurrence and development of various diseases, such as the gut-brain axis and the gut-liver axis. However, its interaction with miscarriages remains poorly understood. This article reviews the characteristics of gut microbiota and its metabolites in patients with recurrent spontaneous abortion (RSA), the mechanism of gut microbiota inducing RSA, and potential therapeutic strategies. Therefore, it provides a new perspective on the gut microbiota in the pathogenesis and treatment of recurrent abortion, and the prospect of the future research direction of gut microbiota and recurrent abortion is proposed based on existing studies.
最近,肠道微生物群被发现与人体多个器官和系统相关联,在各种疾病的发生和发展中发挥着关键作用,如肠-脑轴和肠-肝轴。然而,其与流产的相互作用仍知之甚少。本文综述了复发性自然流产(RSA)患者肠道微生物群及其代谢产物的特征、肠道微生物群诱导RSA的机制以及潜在的治疗策略。因此,它为肠道微生物群在复发性流产的发病机制和治疗方面提供了一个新的视角,并基于现有研究提出了肠道微生物群与复发性流产未来研究方向的展望。
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