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肠道微生物群与复发性自然流产之间的关系

The Relationship Between Gut Microbiota and Recurrent Spontaneous Abortion.

作者信息

Huang Yiyao, Fang Ruijie, Xiong Ting, Li Wei, Yu Nan

机构信息

Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

出版信息

Microorganisms. 2025 May 4;13(5):1073. doi: 10.3390/microorganisms13051073.


DOI:10.3390/microorganisms13051073
PMID:40431246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114443/
Abstract

Recently, the gut microbiota has been found to be associated with multiple organs and systems in the human body, playing a key role in the occurrence and development of various diseases, such as the gut-brain axis and the gut-liver axis. However, its interaction with miscarriages remains poorly understood. This article reviews the characteristics of gut microbiota and its metabolites in patients with recurrent spontaneous abortion (RSA), the mechanism of gut microbiota inducing RSA, and potential therapeutic strategies. Therefore, it provides a new perspective on the gut microbiota in the pathogenesis and treatment of recurrent abortion, and the prospect of the future research direction of gut microbiota and recurrent abortion is proposed based on existing studies.

摘要

最近,肠道微生物群被发现与人体多个器官和系统相关联,在各种疾病的发生和发展中发挥着关键作用,如肠-脑轴和肠-肝轴。然而,其与流产的相互作用仍知之甚少。本文综述了复发性自然流产(RSA)患者肠道微生物群及其代谢产物的特征、肠道微生物群诱导RSA的机制以及潜在的治疗策略。因此,它为肠道微生物群在复发性流产的发病机制和治疗方面提供了一个新的视角,并基于现有研究提出了肠道微生物群与复发性流产未来研究方向的展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/740357aaa64a/microorganisms-13-01073-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/5fd559a32fed/microorganisms-13-01073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/8e36c701060d/microorganisms-13-01073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/740357aaa64a/microorganisms-13-01073-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/5fd559a32fed/microorganisms-13-01073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/8e36c701060d/microorganisms-13-01073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/12114443/740357aaa64a/microorganisms-13-01073-g003.jpg

相似文献

[1]
The Relationship Between Gut Microbiota and Recurrent Spontaneous Abortion.

Microorganisms. 2025-5-4

[2]
Maternal-fetal immunity and recurrent spontaneous abortion.

Am J Reprod Immunol. 2024-5

[3]
An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion.

Microbiol Spectr. 2022-6-29

[4]
Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion.

Heliyon. 2024-1-17

[5]
Characterization of Vaginal Microbiota in Women With Recurrent Spontaneous Abortion That Can Be Modified by Drug Treatment.

Front Cell Infect Microbiol. 2021

[6]
Traditional Chinese medicine syndrome patterns in immune-related recurrent spontaneous abortion: A cross-sectional observational study based on cluster analysis.

Medicine (Baltimore). 2025-5-30

[7]
Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.

Front Immunol. 2024

[8]
The Role of Immune Cells in Recurrent Spontaneous Abortion.

Reprod Sci. 2021-12

[9]
Study on the clinical value of Vitamin D in recurrent spontaneous abortion: Revisiting the Importance of Vitamin D.

Am J Reprod Immunol. 2024-1

[10]
Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy.

Reprod Biol Endocrinol. 2025-1-22

本文引用的文献

[1]
Effect of Supplementation with a Specific Probiotic ( PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial.

Nutrients. 2025-2-13

[2]
Assessing causal relationships between gut microbiota and abortion: evidence from two sample Mendelian randomization analysis.

Front Endocrinol (Lausanne). 2024

[3]
Immunologic insights in recurrent spontaneous abortion: Molecular mechanisms and therapeutic interventions.

Biomed Pharmacother. 2024-8

[4]
[Guideline for diagnosis and treatment of recurrent spontaneous abortion with integrated traditional Chinese and western medicine].

Zhongguo Zhong Yao Za Zhi. 2024-5

[5]
Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.

Front Immunol. 2024

[6]
JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.

Adv Sci (Weinh). 2024-4

[7]
Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion.

Heliyon. 2024-1-17

[8]
Oral administration of Bifidobacterium longum ES1 reduces endometrial inflammation in women with recurrent pregnancy loss.

Am J Reprod Immunol. 2024-1

[9]
Gut microbiome-targeted therapies for Alzheimer's disease.

Gut Microbes. 2023-12

[10]
Antibiotic-free vaginal microbiota transplant with donor engraftment, dysbiosis resolution and live birth after recurrent pregnancy loss: a proof of concept case study.

EClinicalMedicine. 2023-6-26

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