Department of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai 981-8555, Japan.
Anim Sci J. 2009 Oct;80(5):570-6. doi: 10.1111/j.1740-0929.2009.00673.x.
5'-Uridylic acid (UMP), which is present at high concentrations in cow's colostrum, has been shown to cause a reduction in increased plasma levels of insulin and glucose after ingestion of milk replacer in pre-weaning calves. However, the precise mechanisms of UMP action have not been investigated, and its action has not been investigated in other pre-weaning ruminants. In order to demonstrate whether UMP causes changes in postprandial metabolic and hormonal parameters in pre-weaning goats, 11 Saanen kids were given milk replacer (twice a day) without (n = 5) or with (n = 6) UMP (1 g for each meal, 2 g/day for each head) for 14 days. Analysis of blood samples taken in the morning of day 14 demonstrated that the feeding of milk replacer with UMP abolished the significant changes in postprandial plasma glucose, NEFA, GH and insulin concentrations induced by feeding of milk replacer alone, and demonstrated a tendency to increase IGF-I levels. However, there was no significant difference between the two groups at any sampling time. We conclude that UMP feeding with milk replacer showed a tendency to blunt the postprandial changes in levels of some plasma metabolites and hormones that are induced by replacer alone in pre-weaning goats.
5'-尿苷酸（UMP）在牛初乳中的浓度很高，已被证明可降低断奶前小牛摄入代乳粉后胰岛素和葡萄糖的血浆水平升高。然而，UMP 的作用机制尚未得到研究，其在其他断奶前反刍动物中的作用也尚未得到研究。为了证明 UMP 是否会引起断奶前山羊的餐后代谢和激素参数的变化，11 只 Saanen 羔羊连续 14 天接受代乳粉（每天两次）喂养，无 UMP（n = 5）或有 UMP（每餐 1 克，每天每头 2 克）（n = 6）。第 14 天早晨采集的血液样本分析表明，与单独喂养代乳粉相比，UMP 喂养可消除代乳粉喂养引起的餐后血浆葡萄糖、NEFA、GH 和胰岛素浓度的显著变化，并表现出增加 IGF-I 水平的趋势。然而，在任何采样时间两组之间均无显著差异。我们得出结论，与单独喂养代乳粉相比，代乳粉中添加 UMP 喂养具有使一些由代乳粉单独诱导的血浆代谢物和激素的餐后变化趋于迟钝的趋势。
