Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan.
Anim Sci J. 2009 Jun;80(3):286-90. doi: 10.1111/j.1740-0929.2009.00625.x.
The present study was conducted to clarify the central functions of L-aspartic acid (Asp) and L-asparagine (Asn) during an acute stressful condition in chicks. Intracerebroventricular (i.c.v.) injection of Asp and Asn (0.84 micromol) attenuated the vocalization that normally occurs during social separation stress. Asp decreased the time spent in active wakefulness and induced sedation. Asn had a similar effect to Asp, although somewhat weaker. However, i.c.v. injection of Asp and Asn further enhanced plasma corticosterone release under social separation stress. Taken together, the i.c.v. injection of Asp and Asn has sedative effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis.
本研究旨在阐明在雏鸡急性应激条件下 L-天冬氨酸（Asp）和 L-天冬酰胺（Asn）的中枢功能。脑室内（i.c.v.）注射 Asp 和 Asn（0.84 微摩尔）可减轻社交分离应激时通常发生的发声。Asp 减少了活跃觉醒的时间，并引起镇静。Asn 与 Asp 具有相似的作用，但稍弱一些。然而，在社交分离应激下，脑室内注射 Asp 和 Asn 进一步增强了血浆皮质酮的释放。综上所述，脑室内注射 Asp 和 Asn 在急性应激条件下具有镇静作用，而不涉及下丘脑-垂体-肾上腺轴。
